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| 中文名称 |
Notch 1 TFA
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| 英文名称 |
Notch 1 TFA
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| 包装储存 |
Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
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| 产品详情 |
Notch 1 TFA (Notch homolog 1, translocation-associated) 可基因编码蛋白质 NOTCH 家族的成员。该 I 型跨膜蛋白家族成员具有共同的结构特征，包括由多个表皮生长因子样 (EGF) 重复序列组成的细胞外结构域和由多种不同结构域类型组成的细胞内结构域。
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| 生物活性 |
Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types.
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| 性状 |
Solid
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| 体外研究(In Vitro) |
Notch 1 is shown to promote mouse luminal prostate cell survival and proliferation through the activation of the prosurvival NF-κB pathway.Down-regulation of Notch 1 and Jagged1 in human prostate cancer cell lines decreases in vitro invasion and cell growth. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
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| SequenceShortening |
NH2-CLDQIGEFQCICE-COOH
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| 参考文献 |
[1]. NOTCH1 notch receptor 1 [Homo sapiens (human)] Gene ID: 4851, updated on 28-Oct-2019.[2]. Stoyanova T, et al. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6457-E6466.
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| 溶解度数据 |
In Vitro: H2O : 18.52 mg/mL (11.47 mM; ultrasonic and adjust pH to 9 with NaOH)配制储备液
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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