PRE-084 hydrochloride|75136-54-8|-陌孚医药/Medlife

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PRE-084 hydrochloride

目录号: PL07843 纯度: ≥99%

CAS No. :75136-54-8

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中文名称	PRE-084 hydrochloride
中文别名	1-苯基环己烷羧酸 2-(4-吗啉基)乙基酯盐酸盐;PRE-084 (hydrochloride)
英文名称	PRE-084 hydrochloride
英文别名	PRE-084 (hydrochloride);PRE-084 hydrochloride
Cas No.	75136-54-8
分子式	C₁₉H₂₇NO₃^.HCl
分子量	353.88
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	PRE-084 hydrochloride 是一种高选择性的σ1 受体 (S1R) 激动剂，其 IC₅₀ 值为 44 nM。PRE-084 hydrochloride 具有较好的神经保护作用，可改善小鼠的运动功能和运动神经元的存活率。PRE-084 hydrochloride 还能通过激活 Akt-eNOS 途径来改善大鼠心肌缺血再灌注损伤。
生物活性	PRE-084 hydrochloride is a highly selective σ1 receptor (S1R) agonist, with an IC 50 of 44 nM. PRE-084 hydrochloride exhibits good neuroprotective effects, can improve motor function and motor neuron survival in mice. PRE-084 hydrochloride also can ameliorate myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway.
性状	Solid
体外研究(In Vitro)	PRE-084 hydrochloride (0.1-100 μM; 24 h) protects cultured cortical neurons against β-amyloid toxicity (maximally neuroprotective at 10 μM) and reduces the levels of proapoptotic protein Bax at 10 μM. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay-tbl">
体内研究(In Vivo)	PRE-084 hydrochloride (0.25 mg/kg; i.p.; 3 times a week for 8 weeks) displays beneficial effects on motor performance (improves motor neuron survival, ameliorates paw abnormality and grip strength performance) in wobbler mice, and shows neuroprotective effects (increases the levels of BDNF in the gray matter). PRE-084 hydrochloride (1 mg/kg; i.p.; single) protects the heart by activating the Akt?eNOS pathway in myocardial infarction model. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Marrazzo A, et al. Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity. Neuroreport. 2005 Aug 1;16(11):1223-6. [2]. Peviani M, et al. Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation. Neurobiol Dis. 2014 Feb;62:218-32.

溶解度数据	In Vitro: DMSO : ≥ 34 mg/mL (96.08 mM)H₂O : 33.33 mg/mL (94.18 mM; ultrasonic and warming and heat to 60°C)

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