Nω-Propyl-L-arginine hydrochloride|2321366-46-3|(N-omega-Propyl-L-arginine hydrochloride)-陌孚医药/Medlife

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Nω-Propyl-L-arginine hydrochloride (Synonyms: N-omega-Propyl-L-arginine hydrochloride)

目录号: PL07822 纯度: ≥98.0%

CAS No. :2321366-46-3

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中文名称	Nω-Propyl-L-arginine hydrochloride
英文名称	Nω-Propyl-L-arginine hydrochloride
英文别名	N-omega-Propyl-L-arginine (hydrochloride);Nomega-Propyl-L-arginine (hydrochloride);Nω-Propyl-L-arginine hydrochloride
Cas No.	2321366-46-3
分子式	C₉H₂₁ClN₄O₂
分子量	252.74
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride 是一种高效、竞争性、高选择性的神经型一氧化氮合酶 (nNOS) 抑制剂，K_i为 57 nM。Nω-Propyl-L-arginine hydrochloride 对 nNOS 的选择性是内皮型一氧化氮合酶 (eNOS) 的 149 倍。
生物活性	Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a K i of 57 nM. Nω-Propyl-L-arginine hydrochloride displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS).
性状	Oil
体内研究(In Vivo)	Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride (20 mg/kg; i.p.) blocks both phencyclidine-induced disruption of prepulse inhibition and phencyclidine-induced stimulation of locomotor activity. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Zhang HQ, et al. Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine. J Med Chem. 1997 Nov 21;40(24):3869-70. [2]. Klamer D, et al. The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice. Eur J Pharmacol. 2004 Oct 25;503(1-3):103-7.

溶解度数据	In Vitro: DMSO : 25 mg/mL (98.92 mM; Need ultrasonic and warming) H₂O : 25 mg/mL (98.92 mM; Need ultrasonic and warming)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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