Eledoisin|69-25-0|(依来多辛; Eledone peptide)-陌孚医药/Medlife

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Eledoisin (Synonyms: 依来多辛; Eledone peptide)

目录号: PL07712 纯度: ≥98%

CAS No. :69-25-0

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中文名称	Eledoisin
中文别名	依来多辛;醋酸依来多辛;醋酸依来多辛 Eledoisin Acetate;醋酸依来多辛 EledoisinAcetate;麝香蛸毒肽;依来多辛(Eledoisin)
英文名称	Eledoisin
英文别名	Eledoisin;5-Oxo-L-prolyl-L-prolyl-L-seryl-L-lysyl-L-aspartyl-L-alanyl-L-phenylalanyl-L-isoleucylglycyl-L-leucyl-L-methioninamide;Eledoisin Acetate;Eledone peptide;Eledosin Acetate;5-Oxo-L-Pro-L-Pro-L-Ser-L-Lys-L-Asp-L-Ala-L-Phe-L-Ile-Gly-L-Leu-L-Met-NH2;ELEDOSIN;GLP-PRO-SER-LYS-ASP-ALA-PHE-ILE-GLY-LEU-MET-NH2;pEPSKDAFIGLM-NH2;PGLU-PRO-SER-LYS-ASP-ALA-PHE-ILE-GLY-LEU-MET-NH2;PYR-PRO-SER-LYS-ASP-ALA-PHE-ILE-GLY-LEU-MET-NH2;PYR-PSKDAFIGLM-NH2;BDBM50194558;SCHEMBL158143;C54-H85-N13-O15-S;Eledoisine;Eledoisin [INN];ELD-950;C20029;CHEBI:135903;BRN 4796573;AKOS024456851;Tox21_112815;DTXCID9026926;OKY3285J18;NTOC00000202-01;UNII-OKY3285J18;Eledoisine [INN-French];CAS-69-25-0;Eledoisina;D07936;69-25-0;CHEMBL373569;GTPL2086;Eledoisinum;FI 6225 TF/Ocoa;ELD 950;DTXSID1046926;C54H85N13O15S;D0U9IB;NCGC00167276-01;Eledoisina [INN-Spanish];Eledoisin (INN);ELEDOISIN;Q5358600;5-oxo-L-prolyl-L-prolyl-L-seryl-L-lysyl-L-alpha-aspartyl-L-alanyl-L-phenylalanyl-L-isoleucylglycyl-L-leucyl-L-methioninamide
Cas No.	69-25-0
分子式	C₅₄H₈₅N₁₃O₁₅S
分子量	1188.40
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	Eledoisin (Eledone peptide) 是 NK2 和 NK3 受体的特异性激动剂。
生物活性	Eledoisin (Eledone peptide) is a specific agonist of NK2 and NK3 receptors.
性状	Solid
IC50 & Target[1][2]	NK2 NK3
体外研究(In Vitro)	Eledoisin (Eledone peptide) increases the value recorded under basal conditions by 24.5±3.7%; this stimulation is significantly (P<0.01) lowered to 13.1±1.9% by the simultaneous presence of CP99994. The same protocol is also used to characterize the sensitivity of Eledoisin stimulation to 0.1 μM SR48968 or 0.1 μM SB222200. SR48968 significantly (P < 0.01) lower the stimulation by Eledoisin, while SB222200 has no effect. Eledoisin stimulation is reduced by CP99994 and SR48968, NK1 and NK2 antagonists, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Eledoisin (Eledone peptide; 0.1-1 nmol/kg) injected into rats produces a biphasic cardiovascular response that consists of an initial fall of systemic blood pressure (8-15 mm Hg) followed by a rise (20-22 mm Hg). Intracerebroventricular injection of Eledoisin produces an enhancement of grooming and scratching behavior in mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	{Glp}-PSKDAFIGLM-NH2
Sequence	{Glp}-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2
参考文献	[1]. Lippe C, et al. Eledoisin and Kassinin, but not Enterokassinin, stimulate ion transport in frog skin. Peptides. 2004 Nov;25(11):1971-5. [2]. Severini C, et al. The tachykinin peptide family. Pharmacol Rev. 2002 Jun;54(2):285-322.

溶解度数据	In Vitro: H₂O : 18.15 mg/mL (15.27 mM; Need ultrasonic and warming)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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