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| 中文名称 |
Men 10376 TFA
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| 英文名称 |
Men 10376 TFA
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| 包装储存 |
Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year
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| 产品详情 |
Men 10376 TFA 是一种有效的选择性的 tachykinin NK-2 受体拮抗剂，对大鼠小肠 NK-2 受体的 Ki 值为 4.4 μM。
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| 生物活性 |
Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a K i of 4.4 μM for rat small intestine NK-2 receptor.
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| 性状 |
Solid
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| IC50 & Target[1][2] |
Ki: 4.4 μM (NK-2 receptor, rat small intestine)
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| 体外研究(In Vitro) |
Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM). Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM). has not independently confirmed the accuracy of these methods. They are for reference only.
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| 体内研究(In Vivo) |
Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year
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| SequenceShortening |
DY-{d-Trp}-V-{d-Trp}{d-Trp}-K-NH2
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| Sequence |
Asp-Tyr-{d-Trp}-Val-{d-Trp}-{d-Trp}-Lys-NH2
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| 参考文献 |
[1]. Quartara L, et al. N-terminal truncated analogs of men 10376 as tachykinin NK-2 receptor antagonists. Life Sci. 1992;51(25):1929-36.[2]. Maggi CA, et al. In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J Pharmacol Exp Ther. 1991 Jun;257(3):1172-8.
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| 溶解度数据 |
In Vitro: H2O : 1.43 mg/mL (1.20 mM; Need ultrasonic)配制储备液
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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