ABT-418 hydrochloride|147388-83-8|-陌孚医药/Medlife

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ABT-418 hydrochloride

目录号: PL07662 纯度: ≥99%

CAS No. :147388-83-8

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中文名称	ABT-418 hydrochloride
中文别名	3-甲基-5-[(2s)-1-甲基-2-吡咯烷]异噁唑盐酸盐;3-甲基-5-[(2S)-1-甲基-2-吡咯烷基]异恶唑盐酸盐
英文名称	ABT-418 hydrochloride
英文别名	ABT-418 HYDROCHLORIDE;2,2'-(1,2-PHENYLENEBIS(OXY))DIETHANOL;3-Methyl-5-(1-methyl-2(S)-pyrrolidinyl)-isoxazole hydrochloride salt;3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochloride;CTK8E8449;FT-0692227;KB-32783;LP00151;S-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole;SureCN7130413;ABT-418 HCl;(S)-3-Methyl-5-(1-methylpyrrolidin-2-yl)-isoxazolea€￠HCl;3-Methyl-5-[(2S)-1-Methylpyrrolidin-2-yl]isoxazole hydrochloride;ABT-418 hydrochloride
Cas No.	147388-83-8
分子式	C₉H₁₅ClN₂O
分子量	202.68
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	ABT-418 hydrochloride 是一种高效、选择性的 nAChRs 激动剂，具有增强认知和抗焦虑的作用。ABT-418 hydrochloride 激活胆碱能通道，可用于阿尔茨海默病的研究。
生物活性	ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimers disease.
性状	Solid
IC50 & Target[1][2]	nAChRs
体内研究(In Vivo)	ABT-418 hydrochloride (125.66 μg/kg; i.p.) induces a significant increase in the time spent by the rats in the open arms of the elevated plus maze. Acute administration of ABT-418 (125.66μg/kg; i.p.) also attenuates the anxiogenic-like effect elicited by withdrawal from chronic (-)-nicotine treatment. ABT-418 hydrochloride (0.6 mg/kg; i.p.; daily; for two weeks) effectively improves spatial memory in an animal model of ADHD. ABT-418 hydrochloride significantly enhances the cortical α4 and β2 nAChR subunits and the hippocampal α4 subunit expression. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Brioni JD, et al. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418. J Pharmacol Exp Ther. 1994 Oct;271(1):353-61. [2]. Guo T, et al. A comparative study of the effects of ABT-418 and methylphenidate on spatial memory in an animal model of ADHD. Neurosci Lett. 2012 Oct 18;528(1):11-5.

溶解度数据	In Vitro: H₂O : 11.9 mg/mL (58.71 mM; Need ultrasonic)配制储备液

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