EIPA hydrochloride|1345839-28-2|(L593754 hydrochloride; MH 12-43 hydrochloride; Ethylisopropylamiloride hydrochloride)-陌孚医药/Medlife

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EIPA hydrochloride (Synonyms: L593754 hydrochloride; MH 12-43 hydrochloride; Ethylisopropylamiloride hydrochloride)

目录号: PL07616 纯度: ≥99%

CAS No. :1345839-28-2

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中文名称	EIPA hydrochloride
英文名称	EIPA hydrochloride
英文别名	EIPA hydrochloride;EIPA (hydrochloride);3-amino-6-chloro-N-(diaminomethylidene)-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide;hydrochloride;L593754 hydrochloride;5-(N-ethyl-N-isopropyl) amiloride hydrochloride
Cas No.	1345839-28-2
分子式	C₁₁H₁₉Cl₂N₇O
分子量	336.22
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	EIPA (L593754) hydrochloride 是一种具有口服活性的 TRPP3 通道抑制剂，IC₅₀ 为 10.5 μM。EIPA hydrochloride 可通过抑制 Na⁺/H⁺-exchanger 3 (NHE3) 来促进自噬 (autophagy)。EIPA hydrochloride 也抑制巨胞饮作用 (macropinocytosis)。EIPA hydrochloride 可用于炎症和癌症的研究，如胃癌、结肠癌、胰腺癌。
生物活性	EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC 50 of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na/H-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma.
性状	Solid
IC50 & Target[1][2]	COX-2
体外研究(In Vitro)	EIPA hydrochloride (100 μM, 30 min) suppresses TRPP3-mediated Ca uptake in X. laevis oocytes . EIPA hydrochloride (10-100 μM) reversibly inhibits the basal Na current (IC50: 19.5 μM). EIPA hydrochloride (300 μM, 6h) enhances autophagy through NHE3 (Na/H-exchanger 3) in IEC-18 cells. EIPA hydrochloride (20 μM, 2 h) blocks macropinocytosis-mediated uptake of CA-PZ massively entry in HT-29 cells and MIA PaCa-2 cells. EIPA hydrochloride (30 μM, 3h) attenuates Zinc/Kainate toxicity by decreasing Zn entry in cerebellar granule neurons. EIPA hydrochloride (5-100 μM, 48h) suppresses proliferation of MKN28 cells through up-regulation of p21 expression. EIPA hydrochloride (3 μM, 6 h) inhibits the LPS-induced increase in the level of COX-2 protein. has not independently confirmed the accur
体内研究(In Vivo)	EIPA hydrochloride (Intravenous injection, 1 mg/kg) dose-dependently attenuates the I/R (Ischemia/reperfusion)-induced renal dysfunction in ddY strain mice. EIPA hydrochloride (oral administration, 10 mg/kg) inhibits LPS-induced inflammation in air pouch-type LPS-induced inflammation model. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Dai XQ, et al. Inhibition of TRPP3 channel by MK-870 and analogs. Mol Pharmacol. 2007 Dec;72(6):1576-85. [2]. Shi H, et al. Na+/H+ Exchanger Regulates Amino Acid-Mediated Autophagy in Intestinal Epithelial Cells. Cell Physiol Biochem. 2017;42(6):2418-2429. [3]. Zhu BY, et al. A new HDAC inhibitor cinnamoylphena

溶解度数据	In Vitro: DMSO : 130 mg/mL (386.65 mM; Need ultrasonic)配制储备液

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