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产品总数：60944
| 中文名称 |
Rimeporide
|
|---|---|
| 英文名称 |
Rimeporide
|
| 英文别名 |
Benzamide,N-(aminoiminomethyl)-2-methyl-4,5-bis(methylsulfonyl)-;N-(diaminomethylidene)-2-methyl-4,5-bis(methylsulfonyl)benzamide;N-(Aminoiminomethyl)-4,5-bis(methanesulfonyl)-2-methylbenzamide;Rimeporide [INN];UNII-QH6B4V5743;EMD87580;N-[2-methyl-4,5-bis(methylsulfonyl)-benzoyl]-guanidine;Rimeporide;N-carbamimidoyl-2-methyl-4,5-bis(methylsulfonyl)benzamide
|
| Cas No. |
187870-78-6
|
| 分子式 |
C11H15N3O5S2
|
| 分子量 |
333.38
|
| 包装储存 |
Powder -20°C 3 years；In solvent -80°C 6 months
|
| 产品详情 |
Rimeporide (EMD-87580) 是一种有效的选择性 Na+/H+ 交换泵 (NHE-1) 抑制剂。
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|---|---|
| 生物活性 |
Rimeporide (EMD-87580) is a potent and selective inhibitor of the Na/H exchanger (NHE-1).
|
| 性状 |
Solid
|
| IC50 & Target[1][2] |
NHE1
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| 体外研究(In Vitro) |
Blocking NHE-1 activity has been shown to decrease intracellular Na and Ca overload and pH and Rimeporide (EMD-87580) represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide (EMD-87580) is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent. has not independently confirmed the accuracy of these methods. They are for reference only.
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere.
|
| 储存方式 |
Powder -20°C 3 years；In solvent -80°C 6 months
|
| ClinicalTrial |
|
| 参考文献 |
[1]. F.Porte-Thomé, et al. Development of Rimeporide, a sodium-hydrogen exchanger (NHE-1) inhibitor, for patients with Duchenne muscular dystrophy. Neuromuscular Disorders. October 2015 Oct 25:259-260.
|
| 溶解度数据 |
In Vitro: DMSO : 20 mg/mL (59.99 mM; Need ultrasonic and warming)配制储备液
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|---|
1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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