ORM-10962|763926-98-3|-陌孚医药/Medlife

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ORM-10962

目录号: PL07609 纯度: ≥99%

CAS No. :763926-98-3

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中文名称	ORM-10962
英文名称	ORM-10962
英文别名	2-(4-hydroxypiperidin-1-yl)-N-[6-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]pyridin-3-yl]acetamide;GTPL11161;ORM10962;2-(4-Hydroxypiperidin-1-yl)-N-[6-(2-phenyl-chroman-6-yloxy)-pyridin-3-yl]-acetamide;ORM-10962
Cas No.	763926-98-3
分子式	C₂₇H₂₉N₃O₄
分子量	459.54
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	ORM-10962 是一种有效的、高度选择性的钠钙交换器 (NCX) 抑制剂，对反向和正向模式抑制的 IC₅₀ 值分别为 67 nM 和 55 nM。ORM-10962 具有抗心律失常作用。
生物活性	ORM-10962 is a potent, highly selective sodium-calcium exchanger (NCX) inhibitor, with IC 50 values of 67 and 55 nM for the reverse and forward mode inhibition, respectively. ORM-10962 shows antiarrhythmic effect.
性状	Solid
IC50 & Target[1][2]	NCX.
体外研究(In Vitro)	ORM-10962 (10 nM, 100 nM and 1 μM) decreased the NCX current in dog ventricular myocytes in a concentration-dependent manner with estimated IC50 values of 55 and 67 nM at -80 and at 20 mV, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	ORM-10962 (0.3 mg/kg, IV, once) pre-treatment significantly delays the development and recurrence of ventricular extrasystoles (by about 50%) or ventricular tachycardia (by about 30%) in anesthetized guinea pigs. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Kohajda Z, et al. The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments. PLoS One. 2016 Nov 10;11(11):e0166041. [2]. Oravecz K, et al. Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes. Eur J Pharmacol. 2018 Jan 5;818:278-286.

溶解度数据	In Vitro: DMSO : 250 mg/mL (544.02 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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