MPI-0479605|1246529-32-7|-陌孚医药/Medlife

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MPI-0479605

目录号: PL07538 纯度: ≥99%

CAS No. :1246529-32-7

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中文名称	MPI-0479605
中文别名	MPI-0479605 抑制剂;MPI-0479605
英文名称	MPI-0479605
英文别名	MPI-0479605;9H-Purine-2,6-diamine, N6-cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]-;N6-Cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]-9H-purine-2,6-diamine
Cas No.	1246529-32-7
分子式	C₂₂H₂₉N₇O
分子量	407.51
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	MPI-0479605 是一种有效的，选择性的，ATP 竞争性的 Mps1 抑制剂，IC₅₀ 值为 1.8 nM。
生物活性	MPI-0479605 is a potent and selective ATP-competitive inhibitor of Mps1, with an IC 50 of 1.8 nM.
性状	Solid
IC50 & Target[1][2]	Mps1 1.8 nM (IC50) ALK 0.26 μM (IC50
体外研究(In Vitro)	MPI-0479605 is a potent and selective ATP-competitive inhibitor of Mps1, with an IC50 of 1.8 nM. MPI-0479605 (0.1-10 μM) reduces cell viability of HCT-116 cells in a dose-dependent manner. MPI-0479605 shows severe defects in the ability to align chromosomes at the metaphase plate, but causes complete cytokinesis. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	MPI-0479605 (30 mg/kg daily or 150 mg/kg every fourth day (Q4D), i.p.) inhibits tumor growth by 49% and 74 % in HCT-116 xenografts. However, MPI-0479605 does not show inhibitory activity via daily dosing on the Colo-205 xenografts, and dosing every four days causes 63% tumor growth inhibition (TGI). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Tardif KD, et al. Characterization of the cellular and antitumor effects of MPI-0479605, a small-molecule inhibitor of the mitotic kinase Mps1. Mol Cancer Ther. 2011 Dec;10(12):2267-2275.

溶解度数据	In Vitro: DMSO : 11 mg/mL (26.99 mM; Need ultrasonic and warming)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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