MSC-4381|2445185-57-7|-陌孚医药/Medlife

您当前的位置：

MSC-4381

目录号: PL07524 纯度: ≥98%

CAS No. :2445185-57-7

商品编号	规格	价格	会员价
PL07524-5mg	5mg	¥6305.45	请登录
PL07524-10mg	10mg	¥10138.18	请登录
PL07524-50mg	50mg	询价	询价
PL07524-100mg	100mg	询价	询价
PL07524-10mM*1mLinDMSO	10mM*1mLinDMSO	¥6936.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	MSC-4381
英文名称	MSC-4381
英文别名	2-Pyridinecarboxylic acid, 5-[2-[5-chloro-2-[[(5-ethoxy-8-quinolinyl)sulfonyl]amino]phenyl]ethynyl]-4-methoxy-;MSC-4381
Cas No.	2445185-57-7
分子式	C₂₆H₂₀ClN₃O₆S
分子量	537.97
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	MSC-4381 (MCT4-IN-1) 是一种口服有效的，选择性的单羧酸转运蛋白 4 (MCT4/SLC16A3) 抑制剂，IC₅₀ 值为 77 nM，K_i 值为 11 nM。MSC-4381 靶向与 MCT4 的胞质域。MSC-4381 导致高表达 MCT4 细胞中乳酸流出的抑制和细胞活力的降低。MSC-4381 具有用于 MCT4 转运蛋白研究的潜力。
生物活性	MSC-4381 (MCT4-IN-1) is an orally active and selective monocarboxylate transporter 4 (MCT4/SLC16A3) inhibitor with an IC 50 of 77 nM and a K i of 11 nM. MSC-4381 targets to the cytosolic domain of MCT4. MSC-4381 results in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells. MSC-4381 has the potential for MCT4 transporter inhibition research.
性状	Solid
IC50 & Target[1][2]	MCT4 77 nM (IC50) MCT4 11 nM (Ki)
体外研究(In Vitro)	MSC-4381 (compound 18n) inhibits lactate efflux in the MDA-MB-231 cell line with an IC50 of 1 nM. The on-target activity is confirmed with a Ki of 11 nM by fluorescence cross-correlation spectroscopy (FCCS). MSC-4381 does not inhibit lactate efflux to a similar extent in SNU-398 and MiaPaca2, and only 600-fold less in RT-4 cell lines. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	MSC-4381 (compound 18n; 30 mg/kg; PO; single dose) only combined with MCT1/2 inhibitor exhibits a significant tumoral intracellular lactate accumulation. MSC-4381 (30 mg/kg/day; for 15 days) shows no significant antitumor activity. MSC-4381 (0.2 mg/kg; iv) has a T 1/2 of 1 hours, a CL of 0.33 L/h?kg, a C max of 489 ng/mL and a V ss of 0.4 L/kg for mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Timo Heinrich, et al. Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology. J Med Chem. 2021 Aug 26;64(16):11904-11933.

溶解度数据	In Vitro: DMSO : 83.33 mg/mL (154.90 mM; ultrasonic and warming and heat to 60°C)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation