Brofaromine|63638-91-5|(CGP 11305A)-陌孚医药/Medlife

您当前的位置：

Brofaromine (Synonyms: CGP 11305A)

目录号: PL07475 纯度: ≥98%

CAS No. :63638-91-5

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Brofaromine
中文别名	溴法罗明
英文名称	Brofaromine
英文别名	Brofaromine;4-(7-Bromo-5-methoxy-1-benzofuran-2-yl)piperidine;4-(7-Bromo-5-methoxy-2-benzofuranyl)piperidine;Brofaremine;Brofaromina;Brofaromina [Spanish];Brofaromine [INN];Brofarominum;Brofarominum [Latin];CGP 11305;Piperidine, 4-(7-bromo-5-methoxy-2-benzofuranyl)-;Piperidine, 4-(7-bromo-5-methoxy-2-benzofuranyl)-, hydrochloride;UNII-6WV4B8Q07H
Cas No.	63638-91-5
分子式	C₁₄H₁₆NO₂Br
分子量	310.19
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Brofaromine (CGP 11305A) 是一种单胺氧化酶 (MAO) 抑制剂，抑制 MAO-A，IC₅₀ 为 0.2 μM。
生物活性	Brofaromine (CGP 11305A) is a monoamine oxidase (MAO) inhibitor with IC 50 of 0.2?μM for MAO-A.
性状	Solid
IC50 & Target[1][2]	IC50: 0.2 ?μM (MAO-A)
体外研究(In Vitro)	In order to assess whether the protective effect is related to the inhibition of the MAO-A or due to another mechanism, the effect of Brofaromine (CGP 11305A, BRO) is determined on the activity of MAO-A in cultured cortical cells. It shows, firstly, that cultured cortical cells have a significant MAO-A activity, and secondly, that Brofaromine inhibits the enzyme in a concentration-dependent manner. The IC50 is 0.19?μM for Brofaromine . Hill coefficient is 0.96. The enzyme is almost completely inhibited at 10?μM . Brofaromine inhibits MAO-A activity of our cultured cortical cells in a concentration-dependent manner. The IC50 range of Brofaromine is 0.01?μM to 0.1?μM. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Boland A, et al. Pirlindole and dehydropirlindole protect rat cultured neuronal cells against oxidative stress-induced cell death through a mechanism unrelated to MAO-A inhibition. Br J Pharmacol. 2002 Feb;135(3):713-20.

溶解度数据	In Vitro: DMSO : 250 mg/mL (805.96 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品