GSK-LSD1 dihydrochloride|2102933-95-7|-陌孚医药/Medlife

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GSK-LSD1 dihydrochloride

目录号: PL07493 纯度: ≥98.0%

CAS No. :2102933-95-7

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中文名称	GSK-LSD1 dihydrochloride
中文别名	GSK-LSD1 Dihydrochloride
英文名称	GSK-LSD1 dihydrochloride
英文别名	GSK-LSD1 Dihydrochloride;GSK-LSD1 dihydrochloride
Cas No.	2102933-95-7
分子式	C₁₄H₂₂Cl₂N₂
分子量	289.24
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	GSK-LSD1 dihydrochloride 是有效，选择性，不可逆的赖氨酸特异性脱甲基酶 (LSD1) 抑制剂，IC₅₀ 值为 16 nM。
生物活性	GSK-LSD1 dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC 50 of 16 nM.
性状	Solid
IC50 & Target[1][2]	IC50: 16 nM (LSD1)
体外研究(In Vitro)	GSK-LSD1 shows more than 1000 fold selectivity over other closely related FAD utilizing enzymes including LSD2, and monoamine oxidases MAO-A, MAO-B. GSK-LSD1 can inhibit KDM1A/LSD1 enzyme activity. GSK-LSD1 induces the formation of LC3-II in U2OS cells. The electronic microscopy shows the formation of autophagosome with GSK-LSD1 treatment. GSK-LSD1 potently inhibits proliferation of varies cancer cell lines by changing gene expression patterns. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Purich D. The Inhibitor Index A Desk Reference on Enzyme Inhibitors, Receptor Antagonists, Drugs, Toxins, Poisons, Biologics, and Therapeutic Leads. ISBN 9781138739215 [2]. Wang Z, et al. Inhibition of H3K4 demethylation induces autophagy in cancer cell lines. Biochim Biophys Acta. 2017 Aug 8;1864(12):2428-2437.

溶解度数据	In Vitro: DMSO : ≥ 62.5 mg/mL (216.08 mM)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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