RIP1/RIP3/MLKL activator 1|2682850-41-3|-陌孚医药/Medlife

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RIP1/RIP3/MLKL activator 1

目录号: PL07389 纯度: ≥97.0%

CAS No. :2682850-41-3

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中文名称	RIP1/RIP3/MLKL activator 1
英文名称	RIP1/RIP3/MLKL activator 1
英文别名	24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-amide, N-[[1-[[4-(1,1-dimethylethyl)phenyl]methyl]-1H-1,2,3-triazol-4-yl]methyl]-3-hydroxy-9,13-dimethyl-2-oxo-, (9β,13α,14β,20α)-;RIP1/RIP3/MLKL activator 1;MS-31075;HY-144828;CS-0435019;2682850-41-3
Cas No.	2682850-41-3
分子式	C₄₃H₅₆N₄O₃
分子量	676.93
包装储存	4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

产品详情	RIP1/RIP3/MLKL activator 1 (Compound 6i) 是一种有效的抗胶质瘤 (anti-glioma) 药物。RIP1/RIP3/MLKL activator 1 通过激活 RIP1/RIP3/MLKL 通路诱导细胞坏死（necroptosis）。 RIP1/RIP3/MLKL activator 1 可透过血脑屏障。
生物活性	RIP1/RIP3/MLKL activator 1 (Compound 6i) is a potent anti-glioma agent. RIP1/RIP3/MLKL activator 1 induces necroptosis through RIP1/RIP3/MLKL pathway. RIP1/RIP3/MLKL activator 1 exerts acceptable BBB permeability.
性状	Solid
IC50 & Target[1][2]	RIP1, RIP3, MLKL
体外研究(In Vitro)	RIP1/RIP3/MLKL activator 1 (Compound 6i) (96 h) shows antiproliferative activities in human glioma cell lines. RIP1/RIP3/MLKL activator 1 (0-4 μM, 0-72 h) exhibits remarkable antiproliferative activity for U251 cells in a time- and concentration-dependent manner. RIP1/RIP3/MLKL activator 1 (10 μM, 0-72 h) shows acceptable stability. RIP1/RIP3/MLKL activator 1 (0-2 μM, 24 h) effectively inhibits the migration of U251 cells. RIP1/RIP3/MLKL activator 1 induces necroptosis through RIP1/RIP3/MLKL pathway, and induces mitochondrial depolarization in U251 cells. RIP1/RIP3/MLKL activator 1 could not induce apoptosis in U251 cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	RIP1/RIP3/MLKL activator 1 (Compound 6i) (2.50 ng/tail; i.v.; 48 h) inhibits U251 cell proliferation in vivo and exerts acceptable BBB permeability. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献	[1]. Yao Feng, et al. Synthesis and biological evaluation of celastrol derivatives as potential anti-glioma agents by activating RIP1/RIP3/MLKL pathway to induce necroptosis. Eur J Med Chem. 2022 Feb 5;229:114070.

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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