CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC 50 value for MMP-9 is ~8 μM.
性状
Solid
IC50 & Target[1][2]
MMP-2 MMP-9
体外研究(In Vitro)
CTTHWGFTLC, CYCLIC TFA inhibits endothelial and tumor cell migration in vitro. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
CTTHWGFTLC, CYCLIC TFA inhibits tumor progression in vivo, in mouse models. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years;-20°C 1 ye
[1]. Medina OP, et al. Binding of novel peptide inhibitors of type IV collagenases to phospholipid membranes and use in liposome targeting to tumor cells in vitro. Cancer Res. 2001 May 15;61(10):3978-85.