T-26c|869296-13-9|-陌孚医药/Medlife

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T-26c

目录号: PL07409 纯度: ≥99%

CAS No. :869296-13-9

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中文名称	T-26c
中文别名	T-26c
英文名称	T-26c
英文别名	T-26c;4-[[2-[(3-Methoxyphenyl)methylcarbamoyl]-4-oxo-3H-thieno[2,3-d]pyrimidin-5-yl]methoxymethyl]benzoic acid;4-[[[1,4-Dihydro-2-[[[(3-methoxyphenyl)methyl]amino]carbonyl]-4-oxothieno[2,3-d]pyrimidin-5-yl]methoxy]methyl]-benzoic acid; 4-[[[[2-[[[[3-(Methyloxy)phenyl]methyl]amino]carbonyl]-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl]methyl]oxy]methyl]benzoic acid;4-[[[[2-[[[[3-(Methyloxy)phenyl]methyl]amino]carbonyl]-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl]methyl]oxy]methyl]benzoic acid
Cas No.	869296-13-9
分子式	C₂₄H₂₁N₃O₆S
分子量	479.51
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	T-26c 是一种高效的选择性基质金属蛋白酶-13 (MMP-13) 抑制剂，IC₅₀ 值为 6.75 pM。比对其他相关金属酶的选择性高 2600 倍。
生物活性	T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC 50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes.
性状	Solid
IC50 & Target[1][2]	IC50: 6.75 pM (MMP-13)
体外研究(In Vitro)	T-26c significantly inhibits the breakdown of collagen (87.4% inhibition at 0.1 μM) in IL-1β and oncostatin M stimulated cartilage. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	T-26c is well absorbed in all species at the oral dose of 10–20 mg/kg. Oral administration of the disodium salt formulations of T-26c to guinea pigs results in significant increases in AUC (8357 ng h/mL) and C max (1445 ng/ mL) compared with those of the free acid T-26c (AUC = 6478 ng h/ mL and C max = 911 ng/mL). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Nara H, et al. Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site. Bioorg Med Chem. 2014 Oct 1;22(19):5487-505.

溶解度数据	In Vitro: DMSO : 15.62 mg/mL (32.57 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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