Metformin|657-24-9|(二甲双胍; 1,1-Dimethylbiguanide)-陌孚医药/Medlife

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Metformin (Synonyms: 二甲双胍; 1,1-Dimethylbiguanide)

目录号: PL07379 纯度: ≥99%

CAS No. :657-24-9

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中文名称	Metformin
中文别名	二甲双胍;甲福明;双甲胍;1,1-二甲基双胍;降糖片
英文名称	Metformin
英文别名	metformin;Biguanide,1,1-dimethyl- (6CI,8CI);1,1-Dimethylbiguanide;Cidophage;DMGG;Dimethylbiguanide;Emiphage;Ficonax;Fluamine;Flumamine;Gliguanid;Glucofine;Haurymelin;Metiguanide;Metphage;N,N-Dimethyl-imidodicarbonimidic diamide;N,N-Dimethylbiguanide;N,N-Dimethyldiguanide;N1,N1-Dimethylbiguanide;NNDG;N'-Dimethylguanylguanidine;Siofor;3-(diaminomethylidene)-1,1-dimethylguanidine;Diabetosan;Diabex;Glucophage;Glumetza;Meloxicam BP;Metforminum;N,N-dimethyl-biguanide;N,N-dimethylbiguanidine;N,N-dimethylimidodicarbonimidic diamide;USP;1-Carbamimidamido-N,N-dimethylmethanimidamide;Melbin;Metformina;Metformine;Glifage;Dimethyldiguanide;Metformina [DCIT];Imidodicarbonimidic diamide, N,N-dimethyl-;Metformina [Spanish];Metforminum [INN-Latin];Metformine [INN-French];Metformin [USAN:INN:BAN];Epigenase m6A Demethylase Activity;Inhibition Assay Kit (Colorimetric);Metformin
Cas No.	657-24-9
分子式	C₄H₁₁N₅
分子量	129.16
包装储存	-20°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

产品详情

Metformin (1,1-Dimethylbiguanide) 抑制肝脏中的线粒体呼吸链，导致 AMPK 活化，增强胰岛素敏感性，可用于 2 型糖尿病的研究。Metformin 可以透过血脑屏障，诱导自噬 (autophagy)。

生物活性

Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin can cross the blood-brain barrier and triggers autophagy.

性状

Solid

IC50 & Target[1][2]

AMPK

体外研究(In Vitro)

Metformin (1,1-Dimethylbiguanide) inhibits proliferation of ESCs in a concentration-dependent manner. The IC50 is 2.45?mM for A-ESCs and 7.87?mM for N-ESCs. Metformin shows pronounced effects on activation of AMPK signaling in A-ESCs from secretory phase than in cells from proliferative phase.
Metformin (0-500 μM) decreases glycogen synthesis in a dose-dependent manner with an IC50 value of 196.5 μM in cultured rat hepatocytes.
Metformin shows cell viability and cytotoxic effects on PC-3 cells with IC50 of 5 mM. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Metformin (1,1-Dimethylbiguanide; 100 mg/kg, p.o.) alone, and metformin (25, 50, 100 mg/kg) with isoproterenol groups attenuates myocyte necrosis through histopathological analysis.
Metformin (> 900 mg/kg/day, p.o.) results in moribundity/mortality and clinical signs of toxicity in Crl:CD(SD) rats. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

ClinicalTrial

参考文献

[1]. Soraya H, et al. Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats. Pharmacol Rep. 2012;64(6):1476-84.
[2]. Quaile MP, et al. Toxicity and toxicokinetics of metformin in rats. Toxicol Appl Pharmacol. 2010 Mar 15;243(3):340-7.
[3]. Xue J, et al

溶解度数据	In Vitro: H₂O : 50 mg/mL (387.12 mM; Need ultrasonic)DMSO : 20.83 mg/mL (161.27 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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