Bis-ANS dipotassium|65664-81-5|-陌孚医药/Medlife

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Bis-ANS dipotassium

目录号: PL07191 纯度: ≥98.0%

CAS No. :65664-81-5

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中文名称	Bis-ANS dipotassium
中文别名	4,4'-二苯胺基-1,1'-联萘-5,5'-二磺酸二钾盐;4,4''-二苯胺基-1,1''-联萘-5,5''-二磺酸二钾盐;4,4 -二苯胺基-1,1 -联萘-5,5 -二磺酸二钾盐;4,4-二苯胺-1,1-bi萘-5,5-二磺酸二钾;一缩二季戊四醇六硝酸盐;4,4’-二苯胺基-1,1’-联萘-5,5’-二磺酸二钾盐
英文名称	Bis-ANS dipotassium
英文别名	4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic acid dipotassium salt;4,4´-Dianilino-1,1´-binaphthyl-5,5´-disulfonic Acid Dipotassium Salt;4,4′-Dianilino-1,1′-binaphthyl-5,5′-disulfonic acid dipotassium salt;4,4'-DIANILINO-1,1'-BINAPHTHYL-5, 5'-DISULFONIC ACID;Bis-ANS,4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic acid dipotassium salt;4,4'-DIANILINO-1,1'-BINAPHTHYL-5,5'-DISU LFONIC ACI;4,4'-dianilino-1,1'-binaphthyl-5,5'-di-sulfonic A;4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonic acid,dipot;4,4'-DIANILINO-1,1'-BINAPHTHYL-5,5'-DISULFONIC ACID,POTASSIUM SALT;8-Anilino-1-naphthalenesulfonic Acid Di;BIS-ANS;BIS-ANS DIPOTASSIUM SALT;potassium 8,8'-dianilino-5,5'-binaphthalene-1,1'-disulfonate;Bis-ANS dipotassium
Cas No.	65664-81-5
分子式	C₃₂H₂₂N₂O₆S₂-₂^.₂[K+]
分子量	672.85
包装储存	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Bis-ANS dipotassium 是一种蛋白质荧光探针，Bis-ANS 结合到 tubulin，K_d 为 2 μM。Bis-ANS dipotassium 是一种有效的蛋白质液-液相分离 (LLPS) 的双相调节剂。Bis-ANS dipotassium 低浓度促进 LLPS，高浓度抑制 LLPS。
生物活性	Bis-ANS dipotassium is a fluorescent probe of hydrophobic protein. Bis-ANS binds to tubulin with a K d of 2 μM. Bis-ANS dipotassium is a potent biphasic modulator of protein liquid-liquid phase separation (LLPS). Bis-ANS dipotassium promotes LLPS at low concentrations but suppresses LLPS at high concentrations.
性状	Solid
体外研究(In Vitro)	Bis-ANS is a fluorescent molecule that has been used to probe exposed hydrophobic patches in proteins and to monitor the formation of protein aggregates. Bis-ANS is a bivalent naphthalene sulfonate with aniline moieties. Bis-ANS modulates the liquid-liquid phase separation of TDP-43 low complexity domain (LCD). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. P Horowitz, et al. Bis(1,8-anilinonaphthalenesulfonate). A novel and potent inhibitor of microtubule assembly. J Biol Chem. 1984 Dec 10;259(23):14647-50. [2]. W. Michael Babinchak, et al. Small molecules as potent biphasic modulators of protein liquid-liquid phase separation. Nature Communications volume 11, Article number: 5574 (2020)

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