Camptothecin-d5|1329616-37-6|(Campathecin-d-陌孚医药/Medlife

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Camptothecin-d5 (Synonyms: Campathecin-d

目录号: PL07177

CAS No. :1329616-37-6

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PL07177-1mg	1mg	询价	询价
PL07177-5mg	5mg	询价	询价

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中文名称	Camptothecin-d5
中文别名	喜树碱 d5
英文名称	Camptothecin-d5
英文别名	(S)-(+)-Camptothecin-d5;Camptothecin-d5
Cas No.	1329616-37-6
分子式	C₂₀H₁₁D₅N₂O₄
分子量	417.09
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情	Camptothecin-d₅ 是 Camptothecin 的氘代物。Camptothecin (CPT)，一种生物碱，是一种 DNA topoisomerase I (Topo I) 抑制剂，其 IC₅₀ 值为 679 nM。Camptothecin (CPT) 对结直肠癌、乳腺癌、肺癌和卵巢癌具有强大的抗肿瘤活性，通过改变人类癌细胞中的 miRNA 表达模式来调节 hypoxia-inducible factor-1α (HIF-1α) 活性。
生物活性	Camptothecin-d 5 is the deuterium labeled Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells[2][3].
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Luzzio MJ, et al. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of

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