Amatuximab|931402-35-6|(MORab-009)-陌孚医药/Medlife

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Amatuximab (Synonyms: MORab-009)

目录号: PL07095 纯度: ≥96%

CAS No. :931402-35-6

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PL07095-10mg	10mg	¥18545.45	请登录
PL07095-50mg	50mg	询价	询价
PL07095-100mg	100mg	询价	询价

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中文名称	Amatuximab
英文名称	Amatuximab
英文别名	MORAb 009;Amatuximab
Cas No.	931402-35-6
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情

Amatuximab (MORab-009) 是一种针对细胞表面间皮素 (MSLN) 的嵌合人源化 IgG1/k 单抗。Mesothelin 是一种糖基磷脂酰肌醇 (GPI) 锚定的膜糖蛋白，存在于有限的正常成人组织中，如间皮。

生物活性

Amatuximab (MORab-009) is a chimeric, humanized IgG1/k MAb that targets the cell surface mesothelin (MSLN). Mesothelin is a glycosylphosphatidyl inositol (GPI)-anchored membrane glycoprotein, which is present in a restricted set of normal adult tissues such as the mesothelium.

性状

Liquid

体外研究(In Vitro)

Amatuximab (MORAb-009) is a mouse-human chimeric monoclonal antibody with a selective affinity for MSLN. In vitro, amatuximab elicits antibody-dependent cellular cytotoxicity (ADCC) against mesothelin expressing tumor cell lines and inhibits heterotypic cell adhesion of mesothelin-positive tumor cells to CA125-expressing tumor cells. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

In tumor xenograft studies, combination treatment with amatuximab plus chemotherapy led to a greater reduction in the growth of mesothelin-expressing tumors than either Amatuximab or chemotherapy alone. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

ClinicalTrial

参考文献

[1]. Hassan R, et al. Phase II clinical trial of amatuximab, a chimeric antimesothelin antibody with pemetrexed and cisplatin in advanced unresectable pleural mesothelioma. Clin Cancer Res. 2014;20(23):5927-5936.
[2]. Baldo P, et al. Amatuximab and novel agents targeting mesothelin for solid tumors. Onco Targets Ther. 2017;10:5337-5353. Published 2017 Nov 8.

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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