CP-31398 dihydrochloride|1217195-61-3|-陌孚医药/Medlife

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CP-31398 dihydrochloride

目录号: PL07012 纯度: ≥99%

CAS No. :1217195-61-3

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中文名称	CP-31398 dihydrochloride
中文别名	醋酸氯己定杂质C
英文名称	CP-31398 dihydrochloride
英文别名	CP-31398 Dihydrochloride Hydrate;CP 31398 dihydrochloride;N-[2-(1H-1,2,4-triazol-5-ylmethyl)-3,4-dihydro-1H-isoquinolin-6-yl]-2-[4-(trifluoromethyl)phenyl]benzamide;CP-31398 dihydrochloride
Cas No.	1217195-61-3
分子式	C₂₆H₂₂N₅OF₃
分子量	477.48
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情	CP-31398 dihydrochloride 在 p53 突变或野生型的癌细胞中，稳定 p53 的活性构象、促进 p53 的活性。
生物活性	CP-31398 dihydrochloride stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.
性状	Solid
体外研究(In Vitro)	CP-31398 (36.75 μM, 16 h) induces p21 in p53-mutant cells. CP-31398 (15 μg/mL, 20 hours) could induce apoptosis and cell cycle arrest in SW480 cells. has not independently confirmed the accuracy of these methods. They are for reference only.Western Blot Analysis
体内研究(In Vivo)	CP-31398 (100 mg/kg, orally) exhibits significant anti-tumor activity in mice models. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Small human tumor xenografts in mice.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. B A Foster, et al. Pharmacological rescue of mutant p53 conformation and function. Science. 1999 Dec 24;286(5449):2507-10. [2]. Rishu Takimoto, et al. The Mutant p53-Conformation Modifying Drug, CP-31398, Can Induce Apoptosis of Human Cancer Cells and Can Stabilize Wild-Type p53 Protein. Cancer Biol Ther. Jan-Feb 2002;1(1):47-55.

溶解度数据	In Vitro: H₂O : ≥ 100 mg/mL (229.68 mM)DMSO : 8.33 mg/mL (19.13 mM; ultrasonic and warming and heat to 65°C)

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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