Oxotremorine M iodide|3854-04-4|(碘化氧化震颤素M)-陌孚医药/Medlife

您当前的位置：

Oxotremorine M iodide (Synonyms: 碘化氧化震颤素M)

目录号: PL06876 纯度: ≥98.0%

CAS No. :3854-04-4

商品编号	规格	价格	会员价
PL06876-10mg	10mg	¥618.18	请登录
PL06876-50mg	50mg	¥989.09	请登录
PL06876-100mg	100mg	¥1730.91	请登录
PL06876-200mg	200mg	询价	询价
PL06876-500mg	500mg	询价	询价
PL06876-10mM*1mLinDMSO	10mM*1mLinDMSO	¥680.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Oxotremorine M iodide
英文名称	Oxotremorine M iodide
英文别名	N,N,N-trimethyl-4-(2-oxopyrrolidin-1-yl)but-3-yn-1-aminium iodide;Oxotremorine M;trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide;Oxotremorine M iodide
Cas No.	3854-04-4
分子式	C₁₁N₂O+^.I-
分子量	303.03
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Oxotremorine M iodide 是一种有效的，非选择性毒蕈碱型乙酰胆碱受体 (mAChR) 激动剂。Oxotremorine M iodide 通过毒蕈碱受体依赖和独立机制增强 NMDA 受体。
生物活性	Oxotremorine M iodide is a potent and non-selective muscarinic acetylcholine receptor (mAChR) agonist. Oxotremorine M iodide potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms.
性状	Solid
体外研究(In Vitro)	Oxotremorine M iodide (0.1, 0.3, 1, 3, 10, 30 μM) inhibits KCNQ2/3 currents in the concentration-dependence. Oxotremorine M iodide elicits a robust phosphoinositide response characterized with an EC50 of 0.22 μM. Oxotremorine M iodide has EC50s of 0.36, 0.52, 1.62, and 1.48 μM for wild-type, M2, M3, and M2/M3 knockout mice, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Oxotremorine M iodide (0.5 mg/kg; s.c.) increases Ddopamine (DA) release in the medial prefrontal cortex (mPFC) and has no effect in the nucleus accumbens (NAC) in male sprague-dawley albino rats weighing 250-350 g. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Zwart R, et al. Oxotremorine-M potentiates NMDA receptors by muscarinic receptor dependent and independentmechanisms. Biochem Biophys Res Commun. 2018 Jan 1;495(1):481-486. [2]. Zwart R, et al. A novel muscarinic receptor-independent mechanism of KCNQ2/3 potassium channel blockadeby Oxotremorine-M. Eur J Pharmacol. 2016 Nov 15;791:221-228.

溶解度数据	In Vitro: DMSO : 125 mg/mL (387.97 mM; Need ultrasonic)H₂O : 8.33 mg/mL (25.85 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation