Methacholine chloride|62-51-1|(醋甲胆碱; Acetyl-β-methylcholine chloride)-陌孚医药/Medlife

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Methacholine chloride (Synonyms: 醋甲胆碱; Acetyl-β-methylcholine chloride)

目录号: PL06887 纯度: ≥98.0%

CAS No. :62-51-1

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中文名称	Methacholine chloride
中文别名	氯化乙酰甲胆碱;氯化醋甲胆碱;氯化乙酰基-B-甲基胆碱;氯化乙酰甲胆碱 USP标准品;氯化乙酰甲基胆碱;硼氢化钾;乙酰-β-甲基氯化胆碱;乙酰基-2-甲基氯化胆碱;氯化乙酰-β-甲基胆碱;醋甲胆碱
英文名称	Methacholine chloride
英文别名	Methacholine Chloride;Acetyl-B-methylcholine chloride;O-Acetyl-β-methylcholine Chloride;1-Propanaminium,2-(acetyloxy)-N,N,N-trimethyl-, chloride (1:1);2-acetyloxypropyl(trimethyl)azanium,chloride;Acetyl-β-methylcholine chloride;Mecholyl Chloride;Acetyl-beta-methylcholine chloride;Provocholine;Amechol;Methacholine (chloride);Mecholine chloride;Acetyl-;A-methylcholine chloride;Methacholinium chloride;1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride;Acetyl-2-methylcholine Chloride;(2-Acetoxypropyl)trimethylammonium chloride;Metacolina cloruro [DCIT];O-Acetyl-beta-methylcholine chloride;Cloruro de metacolina [Spanish];beta-Methylacetylcholine chloride;Chlorure de methacholine [French];Methacholine chloride
Cas No.	62-51-1
分子式	C₈H₁₈ClNO₂
分子量	195.69
包装储存	4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

产品详情

Methacholine (Acetyl-β-methylcholine) choride 是一种有效的毒蕈碱-3 muscarinic-3 (M3) 激动剂。Methacholine choride 直接作用于平滑肌上的乙酰胆碱受体，导致支气管收缩和气道变窄。Methacholine choride 对识别支气管高反应性 (BHR) 显示出高灵敏度。Methacholine choride 可用于测量气道高反应性 (AHR)，作为评估具有哮喘样症状和正常静息呼气流速的个体的诊断辅助

生物活性

Methacholine (Acetyl-β-methylcholine) choride is a potent muscarinic-3 (M3) agonist. Methacholine choride acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine choride shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine choride can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates.

性状

Solid

体内研究(In Vivo)

Methacholine choride (0.5 μg/kg plus 5 μg/kg/min for 30 min) induces bronchoconstriction in dogs.
Methacholine choride (0.5 mg/kg; i.v.) induces bronchoconstriction was inhibited by bradykinin (4-40 μg/kg; i.v.) in a a dose-dependent manner in mouse. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

ClinicalTrial

参考文献

[1]. Cohen J, et al. Relationship between airway responsiveness to neurokinin A and methacholine in asthma. Pulm Pharmacol Ther. 2005;18(3):171-176.
[2]. Anderson SD, et al. Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma. Respir Res. 2009;10(1):4. Published 2009 Jan 23.

溶解度数据	In Vitro: DMSO : 100 mg/mL (511.01 mM; Need ultrasonic)H₂O : 100 mg/mL (511.01 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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