VU0119498|79183-37-2|-陌孚医药/Medlife

您当前的位置：

VU0119498

目录号: PL06878 纯度: ≥99%

CAS No. :79183-37-2

商品编号	规格	价格	会员价
PL06878-10mg	10mg	¥741.82	请登录
PL06878-25mg	25mg	¥1360.00	请登录
PL06878-50mg	50mg	¥1978.18	请登录
PL06878-100mg	100mg	¥2967.27	请登录
PL06878-200mg	200mg	询价	询价
PL06878-500mg	500mg	询价	询价
PL06878-10mM*1mLinDMSO	10mM*1mLinDMSO	¥816.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	VU0119498
英文名称	VU0119498
英文别名	1-(4-BROMOBENZYL)INDOLE-2,3-DIONE;1H-Indole-2,3-dione, 1-[(4-bromophenyl)methyl]-;VU0119498
Cas No.	79183-37-2
分子式	C₁₅H₁₀NO₂Br
分子量	316.15
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months

产品详情	VU0119498 是一种泛 G_q mAChR M1，M3，M5 的正变构调节剂 (PAM)，EC₅₀ 值分别为 6.04，6.38 和 4.08 µM。VU0119498 具有抗糖尿病活性。
生物活性	VU0119498 is a pan G q mAChR M1, M3, M5 positive allosteric modulator (PAM), with EC 50 s of 6.04, 6.38, and 4.08 μM, respectively. VU0119498 has antidiabetic activity.
性状	Solid
体外研究(In Vitro)	VU0119498 (0.01-30 μM; 150 s) potentiates Ach responses in M1, M3, and M5-expressing CHO cells, with EC50s of 6.04, 6.38, and 4.08 μM, respectively. VU0119498 (3-20 μM) augments ACh-mediated increasing in insulin secretion and intracellular calcium levels in MIN6-K8 cells. VU0119498 (20 μM; 90 min) enhances ACh-induced insulin release in mouse and human pancreatic islets. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	VU0119498 (0.1-2 mg/kg; a single i.p.) improves glucose tolerance and insulin secretion in mice in a β-cell M3R-dependent fashion. VU0119498 (0.5 mg/kg; a single i.p.) improves glucose tolerance and insulin secretion in obese, glucose-intolerant mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；In solvent -80°C 6 months
参考文献	[1]. Bridges TM, et, al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J Med Chem. 2009 Jun 11;52(11):3445-8. [2]. Bridges TM, et, al. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1972-5.

溶解度数据	In Vitro: DMSO : 50 mg/mL (158.15 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation