Propantheline bromide|50-34-0|(溴丙胺太林)-陌孚医药/Medlife

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Propantheline bromide (Synonyms: 溴丙胺太林)

目录号: PL06862 纯度: ≥95.0%

CAS No. :50-34-0

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中文名称	Propantheline bromide
中文别名	溴丙胺太林;普鲁苯辛;溴丙胺肽林;卡维地洛对羟基代谢物;溴丙胺太林 USP标准品;甘露醇卵黄多粘菌素琼脂 (MYP);(2-羟乙基)二异丙基甲基溴化铵咕吨-9-羧酸酯;普鲁本辛
英文名称	Propantheline bromide
英文别名	propantheline bromide;diisopropyl(methyl)(2-xanthen-9-ylcarbonyloxyethyl)ammonium bromide;Propantheline (bromide);Propantheline Bromid;MYP;(2-Hydroxyethyl)diisopropylmethylammonium bromide xanthene-9-carboxylate;Probantine;propanthelinbromid-;PROPANTHELINE BROMIDE [MART.];Pro-Gastron;EINECS 200-030-6;SR-01000003171-2;HMS2097F15;UNII-UX9Z118X9F;KS-1386;MLS001333690;SCHEMBL40291;2-Propanaminium, N-methyl-N-(1-methylethyl)-N-(2-((9H-xanthen-9-ylcarbonyl)oxy)ethyl)-, bromide;Propanthelini bromidum [INN-Latin];UX9Z118X9F;C23H30NO3.Br;NCGC00255145-01;NCI-C56257;PROPANTHELINE BROMIDE [MI];Propantelina bromuro;NCGC00261699-01;Propanthelini bromidum;Neopepulsan;Propantelina bromuro [DCIT];AKOS015895527;MFCD00050291;HMS2092C19;PROPANTHELINE BROMIDE [INN];SPECTRUM1500511;Propantel;CAS-50-34-0;PROPANTHELINE BROMIDE [USP IMPURITY];Pro-Banthine (TN);N-(2-(9H-xanthene-9-carbonyloxy)ethyl)-N-isopropyl-N-methylpropan-2-aminium bromide;Pantheline;PROPANTHELINE BROMIDE;2-Propanaminium,N-methyl-N-(1-methylethyl)-N-[2-[(9H-xanthen-9-ylcarbonyl)oxy]ethyl]-,bromide;NCGC00094306-01;HMS3714F15;CS-4797;C23-H30-N-O3;CHEMBL1240;Kivatin;NCGC00094306-02;N-methyl-N-(1-methylethyl)-N-{2-[(9H-xanthen-9-ylcarbonyl)oxy]ethyl}propan-2-aminium bromide;SR-01000003171;Xanthene-9-carboxylic acid, ester with (2-hydroxyethyl)diisopropylmethylammonium bromide;methyl-di(propan-2-yl)-[2-(9H-xanthen-9-ylcarbonyloxy)ethyl]azanium bromide;PROPANTHELINE BROMIDE [USP MONOGRAPH];NC00529;Prodixamon;Bromure de propantheline;(2-Hydroxyethyl)diisopropylmethylammonium bromide xanthene-9-carboxylate bromide;N-ISOPROPYL-N-METHYL-N-(2-((9H-XANTHEN-9-YLCARBONYL)OXY)ETHYL)PROPAN-2-AMINIUM BROMIDE;EU-0101014;Pro-Banthine;FT-0603218;Propantheline bromide (JP17/USP/INN);NCGC00094306-05;Propantheline bromide [USP:INN:BAN:JAN];REGID_for_CID_9279;NSC757294;HMS2234M23;NSC 757294;NSC-757294;Tox21_111265_1;2-Propanaminio, N-metil-N-(1-metiletil)-N-[2-[(9H-xanten-9-ilcarbonil) oxi] etil]-, bromuro (1:1);DTXSID2023519;P 8891;PROPANTHELINE BROMIDE [JAN];HMS3886K03;NCGC00015854-10;D00481;Opera_ID_1667;Ercorax;DTXCID203519;AC-13428;Bromuro de proantelina [INN-Spanish];Prestwick_241;MLS001076547;50-34-0;D82053;Propantheline bromide [BAN:INN:JAN];MLS000028703;methyl-[2-[oxo(9H-xanthen-9-yl)methoxy]ethyl]-di(propan-2-yl)ammonium bromide;2-Propanaminium, N-methyl-N-(1-methylethyl)-N-[2-[(9H-xanthen-9-ylcarbonyl)oxy]ethyl]-, bromide;Tox21_302331;HMS3259E04;2-Propanaminium, N-methyl-N-(1-methylethyl)-N-(2-((9H-xanthen-9-ylcarbonyl)oxy)ethyl)-, bromide (1:1);Bromuro de proantelina;CCRIS 6271;Neometantyl;Q27291318;PROPANTHELINE BROMIDE [ORANGE BOOK];CCG-39238;Ammonium, diisopropyl(2-hydroxyethyl)methyl-, bromide, xanthene-9-carboxylate;Ercotina;Diisopropyl(2-hydroxyethyl)methylammonium bromide xanthene-9-carboxylate;HMS1920L18;Tox21_111265;Propantheline bromide, United States Pharmacopeia (USP) Reference Stand...
Cas No.	50-34-0
分子式	C₂₃H₃₀NO₃^.Br
分子量	448.40
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Propantheline bromide 是一种具有口服活性的 mAChR 拮抗剂。Propantheline bromide 可用于研究平滑肌功能障碍、出汗过多、胃、肠或膀胱痉挛、以及不自主排尿的相关疾病研究。

生物活性

Propantheline bromide is an orally active mAChR antagonist. Propantheline bromide can be used in the research of smooth muscle dysfunction, excessive sweating, cramps or spasms of the stomach, intestines or bladder, and involuntary urination.

性状

Solid

IC50 & Target[1][2]

mAChR

体外研究(In Vitro)

Propantheline bromide (10 μM-1 mM) decreases urinary bladder smooth muscle reactivity to Acetylcholine.
has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Propantheline bromide (oral administration, 10-300 mg/kg) decreased the fecal pellet count and the incidences diarrhea in restraint stress-induced bowel dysfunction rats. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. J Mokry, et al. Propantheline and in vitro reactivity of urinary bladder smooth muscle in guinea pigs. Bratisl Lek Listy. 2005;106(4-5):151-4.
[2]. Richard Jewell, et al. Propantheline. xPharm: The Comprehensive Pharmacology Reference. 2007, Pages 1-5.
[3]. S Kobayashi, et al. Effects of YM905, a novel muscarinic M3-receptor antagonist, on experimenta

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (223.02 mM)H₂O : 50 mg/mL (111.51 mM; Need ultrasonic)

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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