Sofpironium bromide|1628106-94-4|(BBI 4000)-陌孚医药/Medlife

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Sofpironium bromide (Synonyms: BBI 4000)

目录号: PL06894 纯度: ≥98%

CAS No. :1628106-94-4

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中文名称	Sofpironium bromide
英文名称	Sofpironium bromide
英文别名	Sofpironium bromide;Sofpironium bromide [USAN];Sofpironium bromide (JAN/USAN/INN);D10989;Q27268000;(3R)-3-((R)-2-Cyclopentyl-2-hydroxy-2-phenylacetoxy)-1-(2-ethoxy-2-oxoethyl)-1-methylpyrrolidin-1-ium bromide;Pyrrolidinium, 3-(((2R)-2-cyclopentyl-2-hydroxy-2-phenylacetyl)oxy)-1-(2-ethoxy-2-oxoethyl)-1-methyl-, bromide (1:1), (3R)-
Cas No.	1628106-94-4
分子式	C₂₂H₃₂BrNO₅
分子量	470.40
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Sofpironium bromide (BBI 4000) 是一种抗胆碱能剂，用于研究原发性腋窝多汗症 (PAH)。Sofpironium bromide 通过抑制应用部位外分泌腺中的 M3 毒蕈碱受体来减少出汗。Sofpironium bromide 对 M1、M2、M4 和 M5 亚型也有很高的亲和力。

生物活性

Sofpironium bromide (BBI 4000) is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium bromide reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium bromide also has a high afnity for the M1, M2, M4 and M5 subtypes.

性状

Solid

体外研究(In Vitro)

Sofpironium bromide is metabolized mainly through non-enzymatic hydrolysis, and also through oxidative metabolism via CYP2D6 and CYP3A4. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Sofpironium bromide exhibits anticholinergic activity by inhibiting the contractile activity of guinea pig ileal tissue in a concentration-dependent manner. In a rat model, Sofpironium bromide reduces footpad sweating induced by Pilocarpine (a muscarinic receptor agonist). has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Julia Paik, et al. Sofpironium Bromide: First Approval. Drugs. 2020 Dec;80(18):1981-1986.

溶解度数据	In Vitro: DMSO : 100 mg/mL (212.59 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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