Deschloroclozapine|1977-07-7|(氯氮平杂质)-陌孚医药/Medlife

您当前的位置：

Deschloroclozapine (Synonyms: 氯氮平杂质)

目录号: PL06892 纯度: ≥99%

CAS No. :1977-07-7

商品编号	规格	价格	会员价
PL06892-10mg	10mg	¥1360.00	请登录
PL06892-50mg	50mg	¥4821.82	请登录
PL06892-100mg	100mg	¥8036.36	请登录
PL06892-200mg	200mg	询价	询价
PL06892-500mg	500mg	询价	询价
PL06892-10mM*1mLinDMSO	10mM*1mLinDMSO	¥1496.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Deschloroclozapine
中文别名	11-(4-甲基-1-哌嗪基)-5H-二苯并[B,E][1,4]二氮杂卓;氯氮平杂质
英文名称	Deschloroclozapine
英文别名	5H-Dibenzo[b,e][1,4]diazepine,11-(4-methyl-1-piperazinyl)-;11-(4-METHYL-1-PIPERAZINYL)-5H-DIBENZO(B,E)(1,4)DIAZEPINE;Dopamine serotonin antagonist-1;11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine;5H-Dibenzo(b,e)(1,4)diazepine, 11-(4-methyl-1-piperazinyl)-;BRN 0761696;11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine;11-(4-Methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine;VQHITFFJBFOMBG-UHFFFAOYSA-N;BDBM50010591;Deschloroclozapine
Cas No.	1977-07-7
分子式	C₁₈H₂₀N₄
分子量	292.38
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months

产品详情	Deschloroclozapine 是氯氮平的代谢物，是一种高效的毒蕈碱 DREADDs 激动剂。Deschloroclozapine 对 DREADD 受体亚型 hM3Dq 和 hM4Di 结合 K_i 值分别为 6.3 和 4.2 nM。[¹¹C]-Deschloroclozapine 是一种有前途的 PET 示踪剂，可用于 DREADD 的影像学检查。
生物活性	Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with K i of 6.3 and 4.2 nM, respectively. [C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging.
性状	Solid
IC50 & Target[1][2]	Ki: 6.3 nM (hM3Dq), 4.2 nM (hM4Di)
体外研究(In Vitro)	Designer Receptors Exclusively Activated by Designer Drugs (DREADD) are a chemogenetic approach for remote manipulation of neuronal activity in freely-moving animals. DREADDs comprise mutated G protein-coupled receptors (GPCRs) that do not respond to their endogenous neurotransmitter, but do respond to an otherwise “inert” exogenous substance. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Deschloroclozapine (0.3?mg/kg; intramuscularly) impairs working memory function in male rhesus macaques (aged between 5 and 6 years and weighing 5.5-7.9?kg). Deschloroclozapine (0.1?mg/kg; i.m) is effective at activating DREADD receptors in vivo and reversibly inducing behavioral effects in monkeys. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；In solvent -80°C 6 months
参考文献	[1]. Maggs JL, et al. The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man. J Pharmacol Exp Ther. 1995;275(3):1463-1475. [2]. Hu F, et al. F-labeled radiotracers for in vivo imaging of DREADD with positron emission tomography. Eur J Med Chem. 2021;213:113047.

溶解度数据	In Vitro: DMSO : 100 mg/mL (342.02 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation