Cyclopentolate hydrochloride|5870-29-1|(DL-Cyclopentolate hydrochloride)-陌孚医药/Medlife

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Cyclopentolate hydrochloride (Synonyms: DL-Cyclopentolate hydrochloride)

目录号: PL06871 纯度: ≥99%

CAS No. :5870-29-1

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中文名称	Cyclopentolate hydrochloride
中文别名	盐酸环喷托酯;环喷托酯系统适应性 EP标准品;盐酸环;盐酸环喷托酯 EP标准品;盐酸环喷托酯 USP标准品;盐酸环喷托酯标准品;环戊通
英文名称	Cyclopentolate hydrochloride
英文别名	2-(Dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate hydrochloride;Cyclopentolate Hydrochloride;Benzeneacetic acid, a-(1-hydroxycyclopentyl)-,2-(dimethylamino)ethyl ester, hydrochloride (1:1);CYCLOPENTOLATE HYDROCHLORIDE, CRM STANDARD;2-Dimethylaminoethyl 1-hydroxy-α-phenylcyclopentaneacetate;2-(1-Hydroxycyclopentyl)-2-phenylacetic acid 2-dimethylaminoethyl ester hydrochloride;2-Dimethylaminoethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate hydrochloride;DL-Cyclopentolate hydrochloride;Cyclopentolate hydrochloride
Cas No.	5870-29-1
分子式	C₁₇H₂₅NO₃^.HCl
分子量	327.85
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情

Cyclopentolate (DL-Cyclopentolate) hydrochloride 是一种阿托品样毒蕈碱受体 (muscarinic receptor) 拮抗剂，对睫状肌毒蕈碱受体的 pK_B 值为 7.8。Cyclopentolate hydrochloride 是眼科常用的抗毒蕈碱剂。

生物活性

Cyclopentolate (DL-Cyclopentolate) hydrochloride is an Atropine-like muscarinic receptors antagonist with a pK B value of 7.8 (on the circular ciliary muscle). Cyclopentolate hydrochloride is an anti-muscarinic agent commonly used in the ophthalmologic practice.

性状

Solid

体内研究(In Vivo)

Survival in rats pretreated with cyclopentolate (20 mg/kg) is 90%. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Eighty Sprague-Dawley rats (acute, lethal organophosphate pesticide

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

ClinicalTrial

参考文献

[1]. ?ner V, Bulut A, ?ter K. The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults. Eye (Lond). 2016;30(7):925‐928.
[2]. Ishikawa H, DeSantis L, Patil PN. Selectivity of muscarinic agonists including (+/-)-aceclidine and antimuscarinics on the human intraocular muscles. J Ocul Pharmacol Ther. 1998;14(4):363‐373.

溶解度数据	In Vitro: DMSO : 250 mg/mL (762.54 mM; Need ultrasonic)H₂O : 100 mg/mL (305.02 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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