Biperiden|514-65-8|(比哌立登; 碧卜利旦; KL 373)-陌孚医药/Medlife

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Biperiden (Synonyms: 比哌立登; 碧卜利旦; KL 373)

目录号: PL06847 纯度: ≥99%

CAS No. :514-65-8

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中文名称	Biperiden
中文别名	比哌立登;安克痉;碧卜利旦;双环哌丙醇;比哌立登 USP标准品;比哌立登-D10;1-(5-双环[2.2.1]庚-2-烯基)-1-苯基-3-(1-哌啶基)丙-1-醇;3-哌啶基-1-苯基-双环庚烯基-1-丙醇;微溶于乙醇,易溶于甲醇;医药级：比哌立登
英文名称	Biperiden
英文别名	biperiden;1-phenyl-3-piperidino-1-(8,9,10-trinorborn-5-en-2-yl)propan-1-ol;1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol;KL 373;1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidyl)propan-1-ol;1-norborn-5-en-2-yl-1-phenyl-3-piperidin-1-yl-propan-1-ol;1-norborn-5-en-2-yl-1-phenyl-3-piperidino-propan-1-ol;Akineton;Beperiden;Biperidene;Biperidene [INN-French];Biperideno;Biperideno [INN-Spanish];Biperidenum;Biperidenum [INN-Latin];Biperidine
Cas No.	514-65-8
分子式	C₂₁H₂₉NO
分子量	311.46
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Biperiden (KL 373) 是一种非选择性毒蕈碱受体 (muscarinic receptor) 拮抗剂，可以与 M1 毒蕈碱受体竞争性结合，从而抑制乙酰胆碱 (acetylcholine) 并增强中枢神经系统中多巴胺信号传导。 Biperiden 可用于帕金森病以及其他相关精神疾病的研究。

生物活性

Biperiden (KL 373) is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden has the potential for the research of Parkinsons disease and other related psychiatric disorders.

性状

Solid

体外研究(In Vitro)

Biperiden (29.6 μg/ml, 72 hours) can significantly induce apoptosis and inhibit proliferation at high doses in human pancreatic ductal adenocarcinoma cells.
has not independently confirmed the accuracy of these methods. They are for reference only.Cell Proliferation Assay

体内研究(In Vivo)

Biperiden (intraperitoneal injection, 10 mg/kg, everyday, 3 weeks) reduces tumor size by 83% in subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells.
Biperiden (intraperitoneal injection, 8 mg/kg, every 8 hours, 10 days) can reduce frequency of spontaneous seizures and extracellular hippocampal glutamate levels while cause a long-term decrease in hippocampal excitability.
has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Leonie Konczalla，et al. Biperiden and mepazine effectively inhibit MALT1 activity and tumor growth in pancreatic cancer. Int J Cancer. 2020 Mar 15;146(6):1618-1630.
[2]. Simone Bittencourt, et al. Modification of the natural progression of epileptogenesis by means of biperiden in the pilocarpine model of epilepsy. Epilepsy Res. 2017 Dec;138:88-97. doi: 10.1016/j.eplepsyres.2017.10.019. Epub 2017 Oct 29.

溶解度数据	In Vitro: DMSO : 50 mg/mL (160.53 mM; Need ultrasonic)配制储备液

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Data Sheet

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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