BMS-779788是LXR的部分激动剂，其对LXRα和LXRβ的IC₅₀值分别为68和 14 μM。

BMS-779788 is a LXR partial agonist with IC 50 values of 68 nM for LXRα and 14 nM for LXRβ.

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IC50: 68 nM (LXRα); 14 nM (LXRβ)

The LXR selective partial agonist BMS-779788 is identified with potent induction of ATP binding transporters ABCA1 and ABCG1 in human whole blood (EC50=1.2 μM, 55% efficacy). has not independently confirmed the accuracy of these methods. They are for reference only.

BMS-779788 induces LXR target genes in blood in vivo with an EC 50 =610 nM, a value similar to its in vitro blood gene induction potency. BMS-779788 is 29- and 12-fold less potent than the full agonist T0901317 in elevating plasma triglyceride and LDL cholesterol, respectively, with similar results for plasma cholesteryl ester transfer protein and apolipoprotein B. In mice BMS-779788 displays peripheral induction of ABCA1 at 3 and 10 mpk doses with no significant elevation of plasma or hepatic triglycerides at these doses, showing an improved profile compared to a full pan-agonist. has not independently confirmed the accuracy of these methods. They are for reference only.

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[1]. Kirchgessner TG, et al. Pharmacological characterization of a novel liver X receptor agonist with partial LXRα activity and a favorable window in nonhuman primates. J Pharmacol Exp Ther. 2015 Feb;352(2):305-14.
[2]. Kick E, et al. Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRβ. Bioorg Med Chem Lett. 2015 Jan 15;25(2):372-7.

In Vitro: DMSO : 100 mg/mL (196.44 mM; Need ultrasonic)配制储备液