DMG-PEG 2000|160743-62-4|-陌孚医药/Medlife

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DMG-PEG 2000

目录号: PL06729 纯度: ≥98.0%

CAS No. :160743-62-4

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PL06729-500mg	500mg	¥4327.27	请登录
PL06729-1g	1g	询价	询价
PL06729-5g	5g	询价	询价

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中文名称	DMG-PEG 2000
英文名称	DMG-PEG 2000
英文别名	Poly(oxy-1,2-ethanediyl), ;A-[(2R)-2,3-bis[(1-oxotetradecyl)oxy]propyl]-;O-methoxy-;Poly(oxy-1,2-ethanediyl), \|A-[(2R)-2,3-bis[(1-oxotetradecyl)oxy]propyl]-\|O-methoxy-;DMG-PEG 2000
Cas No.	160743-62-4
分子式	C₃₄H₆₆O₆
分子量	570.88
包装储存	-20°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情	DMG-PEG 2000 用于 siRNA 转染 (siRNA delivery) 的脂质体的制备，能够提高转染效率。DMG-PEG 2000 也可被用于脂质纳米颗粒制备，用于口服质粒 DNA 的体内传递途径，DMG-PEG 2000 可以提高纳米颗粒的黏液渗透性和传递效率。
生物活性	DMG-PEG 2000 is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles.
性状	Solid
体外研究(In Vitro)	NP-3 (0.05-1.6 mg/mL; 24 hours) does not decrease the cytotoxicity of cells in 293T, HepG2, A549, and HeLa cell lines, but the DPPC and DMG-PEG coated nanoparticles reduce cell cytotoxicity. In addition, the transfection efficiency of DPPC/DMG-PEG/(lPEI/DNA) nanoparticles (NP-3) in 293 cells is improved, and the maximum transfection efficiency (～76% eGFP positive cells) is observed. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	NP-3 (oral administration; 150 μg DNA per mouse; single dose) at 12, 24, and 36 h postadministration, luciferin substrate is intraperitoneally injected to verify its permeability. NP-3 group maintains high luciferase expression in the liver, lung, and intestine areas 12-24 h post-treatment.Additionally, NP-3 exhibits 1.5 times higher signal intensity than that of NP-1 or NP-2 group from 12 to 24 h postoral administration. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Tianqi Nie, et al. Surface Coating Approach to Overcome Mucosal Entrapment of DNA Nanoparticles for Oral Gene Delivery of Glucagon-like Peptide 1.ACS Appl Mater Interfaces. 2019 Aug 21;11(33):29593-29603.

溶解度数据	In Vitro: DMSO : 125 mg/mL (ultrasonic and warming and heat to 60°C)Ethanol : 100 mg/mL (Need ultrasonic)H₂O : 16.67 mg/mL (Need ultrasonic)

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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