Propargyl-PEG2-amine
目录号: PL06525 纯度: ≥98%
CAS No. :944561-44-8
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中文名称
Propargyl-PEG2-amine
中文别名
2-[2-(2-丙炔基氧)乙氧基]乙胺;2-[2-(炔丙基氧)乙氧基]乙胺;2-[2-(2-丙炔-1-基氧基)乙氧基]乙胺
英文名称
Propargyl-PEG2-amine
英文别名
2-[2-(2-Propynyloxy)ethoxy]ethylamine;2-[2-(Propargyloxy)ethoxy]ethylamine;Propyne-PEG2-NH2;Propargyl-PEG2-amine;Propyne-PEG2-amine;BIPG1723;GVHLQHHQXWSDDM-UHFFFAOYSA-N;FCH932465;2-(2-(prop-2-ynyloxy)ethoxy)ethanamine;AK192668;2-(2-Prop-2-ynyloxy-ethoxy)-ethylamine;P2225;3-[2-(2-AMINOETHOXY)ETHOXY]PROP-1-YNE;2-[2-(2-Propyn-1-yloxy)ethoxy]ethanamine (ACI);2-(2-(2-Propyn-1-yloxy)ethoxy)ethylamine;2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethan-1-amine;2-(2-Prop-2-ynoxyethoxy)ethanamine
Cas No.
944561-44-8
分子式
C7H13NO2
分子量
143.18
包装储存
4°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
产品详情
Propargyl-PEG2-amine 是一种不可降解 (non-cleavable) 的 ADC linker,用于抗体偶联药物 (ADCs) 的合成。Propargyl-PEG2-amine 是一种 PROTAC linker,属于 PEG 类。Propargyl-PEG2-NH2 可用于合成一系列 PROTAC 分子。
生物活性
Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
性状
Liquid
IC50 & Target[1][2]
Non-cleavable PEGs
体外研究(In Vitro)
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
4°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
参考文献
[1]. Changchun Wang, et al. A kind of antibody coupling matter and its construction method containing boron ester units polymer. CN108721642A.
[2]. Guangrong Zheng, et al. Bcl-2 proteins degraders for cancer treatment. WO2019144117A1.
溶解度数据
In Vitro: DMSO : 100 mg/mL (698.42 mM; Need ultrasonic)配制储备液
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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