N-Boc-diethanolamine
目录号: PL06497 纯度: ≥99%
CAS No. :103898-11-9
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中文名称
N-Boc-diethanolamine
中文别名
N-叔丁氧羰基二乙醇胺;N-Boc-二乙醇胺;4-异丙基苯基溴化镁,0.5M四氢呋喃溶液;N-叔丁氧羰基二乙胺;二(2-羟乙基)氨基甲酸叔丁酯;N,N-双(2-羟乙基)氨基甲酸叔丁酯;BOC-二乙醇胺;N-叔丁氧羰基二乙胺 1G;N-叔丁氧羰基二乙胺/N-BOC-二乙醇胺
英文名称
N-Boc-diethanolamine
英文别名
tert-Butyl bis(2-hydroxyethyl)carbamate;N-Boc-diethanolamine;Boc-diethanolamine;tert-Butyl N,N-bis(2-hydroxyethyl)carbamate;1-Boc-diethanolamine;tert-Butyl bis(2-hydroxyethyl);Bis(2-hydroxyethyl)amine, N-BOC protected;CarbaMic acid, bis(2-hydroxyethyl)-, 1,1-diMethylethyl ester;Boc-diethanolamine≥ 98% (Assay);N-Boc-diethanolamine >=98.0% (GC);(t-butoxy)-N,N-bis(2-hydroxyethyl)carboxamide;N-BOC diethanolamine;N-tert-butoxycarbonyldiethanolamine;KMUNFRBJXIEULW-UHFFFAOYSA-N;7530AH;t-butyl N,N-bis(2-hydroxye
Cas No.
103898-11-9
分子式
C9H19NO4
分子量
205.25
包装储存
Pure form -20°C 3 years;4°C 2 years
产品详情
N-Boc-diethanolamine 是一种 PROTAC 连接桥,属于 Alkyl/ether 类。N-Boc-diethanolamine 可用于合成一系列 PROTAC 分子。N-Boc-diethanolamine 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。
生物活性
N-Boc-diethanolamine is an Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-diethanolamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
性状
Viscous liquid
IC50 & Target[1][2]
Cleavable Alkyl/ether
体外研究(In Vitro)
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years;4°C 2 years
参考文献
[1]. Philip Stewart Low, et al. Small molecule ligand-targeted drug conjugates for anti-influenza chemotherapy and immunotherapy. WO2020023323A1
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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