Dichlorotricarbonylruthenium (II) dimer;Tricarbonyldichlororuthenium(II) dimer;carbon monoxide,dichlororuthenium;CORM-2;Tetrachlorohexacarbonyldiruthenium;Tricarbonyldichlororuthenium dimer
Cas No.
22594-69-0
分子式
2[Cl2Ru].6[Co]
分子量
512.01
包装储存
4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
产品详情
Tricarbonyldichlororuthenium(II) dimer 是释放 CO 的药理供体。Tricarbonyldichlororuthenium(II) dimer 释放的 CO 阻止了缺血/再灌注 (I/R) 引起的胃粘膜氧化损伤,改善了胃血流量 (GBF) ,降低了系统水平的 DNA 氧化和炎症反应。
生物活性
Tricarbonyldichlororuthenium(II) dimer is a pharmacological donor of CO releasing. CO releases from Tricarbonyldichlororuthenium(II) dimer prevents gastric mucosal oxidative damage induced by ischemia/reperfusion (I/R) improving gastric blood flow (GBF), decreasing DNA oxidation and inflammatory response on systemic level.
性状
Solid
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献
[1]. Magierowska K, et, al. Oxidative gastric mucosal damage induced by ischemia/reperfusion and the mechanisms of its prevention by carbon monoxide-releasing tricarbonyldichlororuthenium (II) dimer. Free Radic Biol Med. 2019 Dec; 145:198-208.
溶解度数据
In Vitro: DMSO : 30 mg/mL (58.59 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)配制储备液