cis-4-Hydroxy-L-proline hydrochloride
目录号: PL06434 纯度: ≥97%
CAS No. :441067-49-8
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中文名称
cis-4-Hydroxy-L-proline hydrochloride
中文别名
顺式-4-羟基-L-脯氨酸盐酸盐;(2S,4S)-4-羟基吡咯烷-2-羧酸盐酸盐;(4S)-4-羟基-L-脯氨酸盐酸盐;4-羟基-L-脯氨酸盐酸盐
英文名称
cis-4-Hydroxy-L-proline hydrochloride
英文别名
(2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride;L-Proline, 4-hydroxy-,hydrochloride, cis-;(2s,4S)-4-hydroxy-L-proline hydrochloride;Cis-4-hydroxy-L-prolineMonohydrochloride;(4S)-4-hydroxy-L-proline hydrochloride;L-Proline, 4-hydroxy-, hydrochloride, (4S)-;Cis-4-Hydroxy-L-Proline Hydrochloride;cis-4-Hydroxy-L-proline, HCl;CIS-4-HYDROXY-L-PROLINE HCL;cis-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride;L-hydroxyproline hydrochloride;KSC496I4R;cis-4-Hydroxy-L-proline HCl salt;cis-4-Hydroxy-L-prolineHydrochloride;H18H279;A
Cas No.
441067-49-8
分子式
C5H10ClNO3
分子量
167.59
包装储存
Powder -20°C 3 years;4°C 2 years
产品详情
cis-4-Hydroxy-L-proline (hydrochloride) 是不可降解 (non-cleavable) 的 ADC linker,用于合成抗体偶联药物 (ADCs)。cis-4-Hydroxy-L-proline (hydrochloride) 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker,可用于合成 PROTAC。
生物活性
cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
性状
Solid
IC50 & Target[1][2]
Non-cleavable
体外研究(In Vitro)
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
参考文献
[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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