2'-Deoxy-2'-fluorocytidine|10212-20-1|-陌孚医药/Medlife

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2'-Deoxy-2'-fluorocytidine

目录号: PL06343 纯度: ≥99%

CAS No. :10212-20-1

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中文名称	2'-Deoxy-2'-fluorocytidine
中文别名	2'-脱氧-2'-氟胞苷;2'-氟脱氧胞苷;2′-氟脱氧胞苷;2'-氟-2'-脱氧胞苷;2 -脱氧-2 -氟胞苷;2\'-脱氧-2-氟胞苷;2’-氟-2’-脱氧胞苷;2’-脱氧-2’-氟胞苷;2’-脱氧-2-氟胞苷;2'-Deoxy-2'-fluorocytidine Hydrate 2'-脱氧-2'-氟胞苷水合物;2''-氟-2''-脱氧胞苷;2-氟-2-脱氧胞苷;2鈥?-Deoxy-2鈥?-Fluorocytidine;2''-脱氧-2-氟胞苷;2'-脱氧-2-氟胞苷;2'-脱氧-2'-氟胞苷水合物;R-(+)-6,6'-双(二苯基磷)-2,2',3,3'-四氢-5,5'-二-1,4-苯并二辛烷;2'-去氧-2'-氟胞嘧啶核苷;2\'-脱氧-2\'-氟胞啶;2'-氟-2'-脱氧胞苷(2'-F-2'-DC)
英文名称	2'-Deoxy-2'-fluorocytidine
英文别名	2'-Deoxy-2'-fluorocytidine;4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;2'-FdC;2'-Fluoro-2'-deoxycytidine;2’-Deoxy-2’-fluoro Cytidine;2'-Deoxy-2'-Fluoro-D-cytidine;2'-Fluoro-2'-deoxy-cytidine;2'-Deoxy-2'-fluorocytidine Hydrate;2`-Deoxy-2`-fluoro Cytidine;2′-Fluoro-2′-deoxycytidine;2'-FC;2'-FLUORO-D-CYTIDINE;RO-8013;2'-FANA-C;NSC 529432;Cytidine, 2'-deoxy-2'-fluoro-;LCY080JPY9;2 -Deoxy-2 -Fluorocytidine;4-amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;NSC529432;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;2'-fluoro-d-cyt
Cas No.	10212-20-1
分子式	C₉H₁₂FN₃O₄
分子量	245.21
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	2'-Deoxy-2'-fluorocytidine 是一种核苷类似物，是刚果出血热病毒 (CCHFV) 复制的有效抑制剂。2'-Deoxy-2'-fluorocytidine 可与 T705 协同作用，增强两种化合物对 CCHFV 复制的抗病毒效力。
生物活性	2-Deoxy-2-fluorocytidine, an nucleoside analog, is a potent inhibitor of Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2′-deoxy-2′-fluorocytidine can act synergistically with T705 to increase the potency of both compounds antiviral effects on CCHFV replication.
性状	Solid
体外研究(In Vitro)	2-Deoxy-2-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC50) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Stephen R Welch, et al. Identification of 2-deoxy-2-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus. Antiviral Res. 2017 Nov;147:91-99.

溶解度数据	In Vitro: H₂O : 5 mg/mL (20.39 mM; ultrasonic and warming and heat to 60°C)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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