Fmoc-Lys-OH hydrochloride
目录号: PL06315 纯度: ≥99%
CAS No. :139262-23-0
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中文名称
Fmoc-Lys-OH hydrochloride
中文别名
Fmoc-L-赖氨酸盐酸盐;芴甲氧羰基-L-赖氨酸盐酸盐;Nα-[(9H-芴-9-基甲氧基)羰基]-L-赖氨酸盐酸盐;Fmoc-L-赖氨酸盐酸盐,Fmoc-Lys-OH hydrochloride;Fmoc-赖氨酸盐酸盐;N-(9-芴甲氧羰基)-L-赖氨酸盐酸盐;Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-lysine Hydrochloride Nα-[(9H-芴-9-基甲氧基)羰基]-L-赖氨酸盐酸盐;Nα-Fmoc-L-赖氨酸盐酸盐;N-甲酰吗啉(NFM);Nα-芴甲氧羰基-L-赖氨酸 盐酸盐;Fmoc-Lys-OH·HCl
英文名称
Fmoc-Lys-OH hydrochloride
英文别名
Fmoc-L-lysine hydrochloride;Fmoc-Lys-OH hydrochloride;Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-lysine Hydrochloride;Fmoc-Lys-OH·HCl;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-aminohexanoic acid hydrochloride;Fmoc-L-lysine HCl;Fmoc-Lys-OH HCl;Fmoc-Lys-OH.HCl;Fmoc-Lys-OH•HCl;N(ALPHA)-FMOC-L-LYSINE HYDROCHLORIDE;Nalpha-Fmoc-L-lysine hydrochloride;4-ForMylMorpholine;Fmoc-Lys-OH inverted exclamation mark currencyHCl;KSC496Q6H;PubChem10025;Nα-Fmoc-L-lysine Hydrochloride;C21H25ClN2O4;L-Lysine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-, monohydrochloride;Fmoc-Lys-OH-HCl;Fmoc-Lys-OH. HCl;Fmoc-L-Lys-OH.HCl;Fmoc-lysine hydrochloride;KSC496
Cas No.
139262-23-0
分子式
C21H25ClN2O4
分子量
404.89
包装储存
4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
产品详情
Fmoc-Lys-OH hydrochloride 是不可降解 (non-cleavable) 的 ADC linker,用于合成抗体偶联药物 (ADCs)。Fmoc-Lys-OH hydrochloride 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker,可用于合成 PROTAC。
生物活性
Fmoc-Lys-OH hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys-OH hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
性状
Solid
IC50 & Target[1][2]
Non-cleavable
体外研究(In Vitro)
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献
[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
溶解度数据
In Vitro: DMSO : 125 mg/mL (308.73 mM; Need ultrasonic)配制储备液
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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