Cyclofenil|2624-43-3|(环芬尼)-陌孚医药/Medlife

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Cyclofenil (Synonyms: 环芬尼)

目录号: PL06324 纯度: ≥95%

CAS No. :2624-43-3

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中文名称	Cyclofenil
中文别名	环芬尼;双醋环烷;环己基亚甲基二苯酚二乙酸酯
英文名称	Cyclofenil
英文别名	(Cyclohexylidenemethylene)bis(4,1-phenylene) diacetate;cyclofenil;(Cyclohexylidenemethylene)-bis(4,1-phenylene) diacetate;Cyclofenil,4,4'-(Cyclohexylidenemethylene)bisphenol1,1'-diacetate;cyclofenyl;f6066;fertodur;h3452;oginex;ondogyne;ondonid;sexadieno;sexovar;(Cyclohexylidenemethanediyl)dibenzene-4,1-diyl diacetate;[4-[(4-Acetyloxyphenyl)-cyclohexylidenemethyl]phenyl] acetate;Cyclophenyl;Cyclopenil;Sanocrisin;Cyclophenil;Rehibin;Sexovid;Neoclym;ICI 48213;Cyclofenilum [INN-Latin];Ciclofenilo [INN-Spanish];H 3452;F 6066;Cyclofenil [INN:BAN:DCF:JAN];4,4'-(Cyclohexylidenemethylene)diphenol diacetate ester;C23H24O4;Bis(p-hydroxyphenyl)cyclohexyldienemethane diacetate;(Cyclohexyliden
Cas No.	2624-43-3
分子式	C₂₃H₂₄O₄
分子量	364.43
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Cyclofenil 是一种选择性雌激素受体 (estrogen receptor) 调节剂和排卵诱导剂。Cyclofenil 对 Vero 细胞中的登革热病毒复制具有抑制作用，EC₅₀ 为 1.62 μM。 Cyclofenil 具有抗登革热病毒的活性。
生物活性	Cyclofenil is a selective estrogen receptor modulator and an ovulation-inducing agent. Cyclofenil shows an inhibitory effect on dengue virus replication in Vero cells with an EC 50 of 1.62 μM. Cyclofenil has anti-dengue-virus activity.
性状	Solid
IC50 & Target[1][2]	Estrogen receptor; Dengue virus
体外研究(In Vitro)	Cyclofenil shows an inhibitory effect on dengue virus (DENV) replication in mammalian cells but not in mosquito cells. Cyclofenil also inhibits the replication of Zika virus. A time-of-addition assay suggested that Cyclofenil may interfere with two stages of the Dengue virus (DENV) life cycle: the translation-RNA synthesis and assembly-maturation stages. The level of intracellular infectious particles decreased more drastically after treatment with Cyclofenil than the viral RNA level do, indicating that the assembly-maturation stage might be the main target of Cyclofenil. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	The number of estrogen receptors α (ERα) and β (ERβ)-immunoreactive (-ir) cells is determined of each stage of the estrous cycle in intact rats. Additionally, the effects of blocking ERα and ERβ on ovulation rate on diestrus-2 or proestrus day through the microinjection of methyl-piperidino-pyrazole (MPP) or Cyclofenil in either side of preoptic-anterior hypothalamic area (POA-AHA) are evaluated. The number of ERα-ir and ERβ-ir cells in POA-AHA varied in each phase of estrous cycle. Either MPP or Cyclofenil in the right side of POA-AHA on diestrus-2 day reduced the ovulation rate, while at proestrus day it was decreased in rats treated in either side with MPP, and in those treated with Cyclofenil in the left side. MPP or Cyclofenil produced a decrease in the surge of luteinizing hormone levels (LH) and an increase in progesterone and follicle stimulating hormone (FSH).
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Tohma D, et al. An estrogen antagonist, cyclofenil, has anti-dengue-virus activity. Arch Virol. 2019 Jan;164(1):225-234. [2]. Arrieta-Cruz I, et al. Estrogen Receptors Alpha and Beta in POA-AHA Region Regulate Asymmetrically Ovulation. Cell Mol Neurobiol. 2019 Nov;39(8):1139-1149.

溶解度数据	In Vitro: DMSO : 100 mg/mL (274.39 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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