tans-4-Hydroxy-D-proline methyl ester hydrochloride|481704-21-6|-陌孚医药/Medlife

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tans-4-Hydroxy-D-proline methyl ester hydrochloride

目录号: PL06201 纯度: ≥98%

CAS No. :481704-21-6

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PL06201-5g	5g	询价	询价
PL06201-10g	10g	询价	询价

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中文名称	tans-4-Hydroxy-D-proline methyl ester hydrochloride
中文别名	反式-4-羟基-L-脯氨酸甲酯盐酸盐;L-羟脯氨酸甲酯盐酸盐;(2S,4R)-4-羟基-L-脯氨酸甲酯;羟脯氨酸甲酯盐酸盐;(2R,4S)-4-羟基吡咯烷-2-羧酸甲酯盐酸盐;(2S,4R)-甲基 4-羟基吡咯烷-2-羧酸盐酸盐;(S)-4-羟基-D-脯氨酸甲酯盐酸盐;反式-4-羟基-D-脯氨酸甲酯盐酸盐;(4S)-4-羟基-D-脯氨酸甲酯盐酸盐
英文名称	tans-4-Hydroxy-D-proline methyl ester hydrochloride
英文别名	(S)-4-Hydroxy-D-proline Methyl Ester Hydrochloride;trans-4-Hydroxy-L-proline methyl ester;4-HYDROXY-L-PROLINE METHYL ESTER HCl;H-HYP-OME HCL;H-L-HYP-OME HCL;HYDROXYPROLINE-OME HCL;L-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE;L-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT;L-4-TRANS-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE;L-4-TRANS-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT;L-TRANS-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT;Methyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride;(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride;(2R,4S)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride;(2S,4R)-2-CARBOMETHOXY-4-HYDROXYPYRROLIDINE HYDROCHLORIDE;(4S)-4-hydroxy-D-Proline methyl ester hydrochloride;1-hydroxy-2-oxopentane;1-Hydroxy-2-pentanone;1-Hydroxy-pentan-2-on;1-hydroxy-pentan-2-one;2-Pentanone,1-hydroxy;4S-hydroxy-1-pyrrolidine-2R-carboxylic acid methyl ester hydrochloride salt;Hydroxymethyl-propyl-keton;l-hydroxy-2-oxopentane;L-hydroxyproline methyl ester hydrochloride;Methyl (2R,4S)-4-hydroxypyrrolidine-2-carboxylate hydrochloride
Cas No.	481704-21-6
分子式	C₆H₁₁NO₃^.HCl
分子量	181.62
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	tans-4-Hydroxy-D-proline methyl ester hydrochloride 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联药物 (ADCs)。tans-4-Hydroxy-D-proline methyl ester hydrochloride 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。
生物活性	tans-4-Hydroxy-D-proline methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
性状	Solid
IC50 & Target[1][2]	Non-cleavable
体外研究(In Vitro)	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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