N-Boc-cis-4-Hydroxy-D-proline|135042-12-5|-陌孚医药/Medlife

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N-Boc-cis-4-Hydroxy-D-proline

目录号: PL06175

CAS No. :135042-12-5

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中文名称	N-Boc-cis-4-Hydroxy-D-proline
中文别名	正-Boc-顺式-4-羟基-D-脯氨酸;N-Boc-顺式-4-羟基-D-脯氨酸;(2R,4R)-N-叔丁氧羰基-4-羟基吡咯烷-2-甲酸;(2R,4R)-N-Boc-4-羟基吡咯烷-2-甲酸;1-Cbz-4-羟甲基哌啶;BOC-(2R,4R)-(+)-4-羟基吡咯烷-2-甲酸(BOC-顺-4-羟基-D-脯氨酸);Boc-D-顺式-Hyp-OH;Boc-顺式-4-羟基-D-脯氨酸
英文名称	N-Boc-cis-4-Hydroxy-D-proline
英文别名	N-Boc-cis-4-Hydroxy-D-proline;(2R,4R)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;BOC-(2R,4R)-(+)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;BOC-CIS-4-HYDROXY-D-PROLINE;BOC-D-CISHYP-OH;N-T-BOC-CIS-4-HYDROXY-D-PROLINE;N-ALPHA-BUTOXYCARBONYL-CIS-4-HYDROXY-D-PROLINE;(2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid;(2R,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid;(2R,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic Acid 1-(1,1-Dimethylethyl) Ester;cis-Boc-D-Hyp-OH;(2R,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid;(2R,4R)-N-Boc-4-hydroxy-2-pyrrolidinecarboxylic acid;(2R,4R)-1-tert-Butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid;(2R,4R)-4-Hydroxypyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester;(2R,4R)-1-[(tert-butoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid;I467853HPL;(4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-D-proline;(2R,4R)-1-tert-butoxycarbonyl-4-hydroxy-pyrrolidine-2-carboxylic acid;1,2-Pyrrolidinedicarboxylic acid,
Cas No.	135042-12-5
分子式	C₁₀H₁₇NO₅
分子量	231.25
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	N-Boc-cis-4-Hydroxy-D-proline 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联药物 (ADCs)。N-Boc-cis-4-Hydroxy-D-proline 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。
生物活性	N-Boc-cis-4-Hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-Hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synth
性状	Solid
IC50 & Target[1][2]	Non-cleavable
体外研究(In Vitro)	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

溶解度数据	In Vitro: DMSO : 100 mg/mL (432.43 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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