SC57666|158959-32-1|-陌孚医药/Medlife

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SC57666

目录号: PL06120 纯度: ≥98%

CAS No. :158959-32-1

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中文名称	SC57666
英文名称	SC57666
英文别名	Benzene,1-fluoro-4-[2-[4-(methylsulfonyl)phenyl]-1-cyclopenten-1-yl]-;SC57666;1-[2-(4-Fluorophenyl)cyclopenten-1-yl]-4-(methylsulfonyl)benzene;1-Fluoro-4-[2-(4-methylsulfonylphenyl)-1-cyclopenten-1-yl]benzene
Cas No.	158959-32-1
分子式	C₁₈H₁₇FO₂S
分子量	316.39
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	SC57666是选择性的 COX2 抑制剂，IC₅₀ 值为26 nM。
生物活性	SC57666 is a selective COX2 inhibitor with an IC 50 of 26 nM.
性状	Solid
IC50 & Target[1][2]	COX-2 26 nM (IC50)
体外研究(In Vitro)	SC57666 inhibits COX2 with an IC50 of 3.2±0.8 nM in CHO cells stably transfected with human COX isozymes, with 1000 fold or more selectivity over COX1 (IC50=6000±1900 nM). has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	SC57666 has been shown to be orally active (ED 50 =1.7 mpk) in the adjuvant-induced arthritis model. No gastric lesions are observed in mice after 5 h when SC57666 is administered intragastrically at 600 mpk. No intestinal damage is observed in rats after 72 h when SC57666 is administered intragastrically at 200 mpk. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Reitz DB, et al. Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally activeCOX2 inhibitors. J Med Chem. 1994 Nov 11;37(23):3878-81. [2]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (316.07 mM)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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