SUN 1334H|607736-84-5|-陌孚医药/Medlife

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SUN 1334H

目录号: PL06112 纯度: ≥95%

CAS No. :607736-84-5

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中文名称	SUN 1334H
中文别名	SUN 1334H
英文名称	SUN 1334H
英文别名	SUN 1334H
Cas No.	607736-84-5
分子式	C₂₃H₂₈Cl₂F₂N₂O₃
分子量	489.38
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	SUN 1334H 是一种有效的，可口服的，选择性的 H1 receptor 拮抗剂，K_i 值为 9.7 nM。
生物活性	SUN 1334H is a potent, orally active, highly selective H1 receptor antagonist, with K i of 9.7 nM.
性状	Solid
IC50 & Target[1][2]	Ki: 9.7 nM (H1 receptor)
体外研究(In Vitro)	SUN-1334H causes potent inhibition of histamine induced contractions of isolated guinea-pig ileum with an IC50 (half the maximal inhibitory concentration) of 0.198 μM. In CHO-K1/hERG cells, SUN-1334H does not modulate hERG K-currents at concentrations as high as 100 μM. SUN-1334H, cetirizine and hydroxyzine cause comparable inhibition of NLF leukocytes, IL-4 and total protein concentrations. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	SUN-1334H potently inhibits histamine-induced bronchospasm over 24 hours following oral administration and completely suppresses histamine-induced skin wheal in beagle dogs and ovalbumin-induced rhinitis in guinea pigs. In skin allergy models, SUN-1334H shows potent reduction of passive and active cutaneous anaphylactic reactions. In central nervous system side effects models, SUN-1334H, desloratadine and fexofenadine are devoid of any significant effects. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Mandhane SN, et al. Preclinical efficacy and safety pharmacology of SUN-1334H, a potent orally active antihistamine agent. Drugs R D. 2008;9(2):93-112. [2]. Mandhane SN, et al. Characterization of anti-inflammatory properties and evidence for no sedation liability for the novel antihistamine SUN-1334H. Int Arch Allergy Immunol. 2010;151(1):56-69.

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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