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| 中文名称 |
Mupadolimab
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|---|---|
| 中文别名 |
莫帕利单抗
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| 英文名称 |
Mupadolimab
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| 英文别名 |
Mupadolimab;Research Grade Mupadolimab(DHD46604)
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| Cas No. |
2451856-97-4
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| 包装储存 |
Please store the product under the recommended conditions in the Certificate of Analysis.
|
| 产品详情 |
Mupadolimab (CPI-006) 是一种 IgG1κ 人源化的 FcγR 结合缺陷抗 CD73 单抗，激活 CD73POS B 细胞。
|
|---|---|
| 生物活性 |
Mupadolimab (CPI-006) is an IgG1κ humanized FcγR binding-deficient anti-CD73 monoclonal antibody (mAb) that activates CD73 B cells.
|
| 性状 |
Liquid
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| IC50 & Target[1][2] |
CD73
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| 体外研究(In Vitro) |
Mupadolimab induces the increased expression of markers associated with B cell maturation and antigen presentation, morphologic transformation to plasmablasts, and increased secretion of IgM and IgG. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 体内研究(In Vivo) |
Mupadolimab (10 mg/kg; i.p.; daily for 15 days) stimulates antigen specific humoral immunity in SARS-CoV-2 infected NSG-SGM3 mice. has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model: NSG-
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis.
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| ClinicalTrial |
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| 参考文献 |
[1]. Miller R A, et al. Clinical results with a B cell activating anti-CD73 antibody for the immunotherapy of Covid-19. medRxiv, 2021.
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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