Figitumumab|943453-46-1|(CP-751871)-陌孚医药/Medlife

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Figitumumab (Synonyms: CP-751871)

目录号: PL06055 纯度: ≥96%

CAS No. :943453-46-1

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中文名称	Figitumumab
中文别名	芬妥木单抗
英文名称	Figitumumab
英文别名	Figitumumab
Cas No.	943453-46-1
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情

Figitumumab (CP-751871) 是一种有效的全人抗胰岛素样生长因子 1 受体 (IGF1R) 单克隆抗体。Figitumumab 可阻止 IGF1 与 IGF1R 结合，IC₅₀ 为 1.8 nM。

生物活性

Figitumumab (CP-751871) is a potent and fully human monoclonal anti–insulin-like growth factor 1 receptor (IGF1R) antibody. Figitumumab prevents IGF1 from binding to IGF1R with an IC 50 of 1.8 nM.

性状

Liquid

IC50 & Target[1][2]

IC50: 1.8 nM (IGF1R)

体外研究(In Vitro)

Figitumumab (CP-751871) (152 pM-10 μM; 3 days) inhibits cancer cell proliferation.
Figitumumab (1 μg/mL; 1 min or 24 h) induces the down-regulation of IGF-1R.
Figitumumab inhibits IGF1-induced autophosphorylation of IGF1R with an IC50 of 0.42 nM, and indirectly inhibits AKT activation.
Figitumumab recognizes the IGF-1R/IR heterodimer complex. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Figitumumab (CP-751871) (31-125 μg/mouse; i.p.; once) induces the down-regulation of tumor associated IGF-1R in mice.
Figitumumab (62.5-500 μg/mouse; i.p.; once) inhibits the growth of s.c. xenografts derived from colon (Colo-205), breast (MCF7), and lung (H460) cancer cell lines in mice. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

ClinicalTrial

参考文献

[1]. Pavlicek A, et al. Molecular predictors of sensitivity to the insulin-like growth factor 1 receptor inhibitor Figitumumab (CP-751,871). Mol Cancer Ther. 2013 Dec;12(12):2929-39.
[2]. Cohen BD, et al. Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871. Clin Cancer Res. 2005 Mar 1;11(5):2063-73.

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