Teplizumab|876387-05-2|(MGA-031; PRV-031)-陌孚医药/Medlife

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Teplizumab (Synonyms: MGA-031; PRV-031)

目录号: PL06062 纯度: ≥99%

CAS No. :876387-05-2

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PL06062-10mg	10mg	询价	询价
PL06062-50mg	50mg	询价	询价
PL06062-100mg	100mg	询价	询价

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中文名称	Teplizumab
英文名称	Teplizumab
英文别名	Teplizumab
Cas No.	876387-05-2
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情

Teplizumab (MGA-031) 是一种 Fc 受体型、非结合类型的抗-人 CD3 的单克隆抗体。Teplizumab 可缓解 β 细胞的功能丧失。Teplizumab 可用于 type 1 型糖尿病的研究。

生物活性

Teplizumab (MGA-031) is a Fc receptor non-binding anti-human CD3 monoclonal antibody. Teplizumab reduces the loss of beta-cell function. Teplizumab can be used in the research of type 1 diabetes.

性状

Liquid

IC50 & Target[1][2]

CD3

体外研究(In Vitro)

Teplizumab (10 ng/mL-10 μg/mL, 5 days) induces human CD8+ T-cell proliferation.
Teplizumab (6 days) increases the expression of CD25 and intracellular CTLA4 on CD8+ cells (freshly isolated PBMCs).
has not independently confirmed the accuracy of these methods. They are for reference only.Cell Proliferation Assay-tbl">

体内研究(In Vivo)

Teplizumab (0.24 mg/kg, i.p.) induces migration of human CD4 T cells to the lamina propria and ablated the treatment effects of the drug on graft survival in NSG mice.
has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

ClinicalTrial

参考文献

[1]. Kevan C Herold, et al. An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes. N Engl J Med. 2019 Aug 15;381(7):603-613.
[2]. Frank Waldron-Lynch, et al. I Analysis of FcR non-binding anti-CD3 mAb in humanized mice identifies novel human gut tropic cells with regulatory function that are found in patients. Sci Transl Med. 2012 Jan 25;4(118):118ra12.

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