Rituximab (anti-CD20)|174722-31-7|-陌孚医药/Medlife

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Rituximab (anti-CD20)

目录号: PL06038 纯度: ≥99%

CAS No. :174722-31-7

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PL06038-10mg	10mg	询价	询价
PL06038-50mg	50mg	询价	询价

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中文名称	Rituximab (anti-CD20)
中文别名	利妥昔单抗;利妥昔单抗美罗华 Rituximab
英文名称	Rituximab (anti-CD20)
英文别名	IDEC 102;IDEC-C 2B8;ImmunoglobulinG 1 (human-mouse monoclonal IDEC-C2B8 g1-chain anti-human antigen CD 20), disulfide withhuman-mouse monoclonal IDEC-C2B8 k-chain, dimer;MabThera;Retuxin;Rituxan;Rituximab;Immunoglobulin G1;Immunoglobulin G1,anti-(human CD20 (antigen)) (human-mouse monoclonal IDEC-C2B8 g1-chain), dis...;Immunoglobulin G1,anti-(human CD20 (antigen)) (human-mouse monoclonal IDEC-C2B8 g1-chain), disulfide withhuman-mouse monoclon;Hsdb 7455;Unii-4F4X42syq6;Ig gamma-1 chain C region;IMMunoglobulin G1,anti-(huMan CD20 (antigen)) (huMan-Mouse Monoclonal IDEC-C2B8 g1-chain), disulfide withhuMan-Mouse Monoclonal IDEC-C2B8 k-chain, diMer;Immunoglobulin G 1 (human-mouse monoclonal idec-C2B8 gamma1-chain anti-human antigen cd 20), disulfide with human-mouse monoclonal idec-C2B8 kappa-chain, dimer;Mab thera
Cas No.	174722-31-7
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情

Rituximab (anti-CD20) 是一种抗 CD20 嵌合单克隆抗体，用于某些自身免疫疾病和癌症的研究。

生物活性

Rituximab (anti-CD20) is an anti-CD20 chimeric monoclonal antibody used to treat certain autoimmune diseases and types of cancer.

性状

Liquid

体外研究(In Vitro)

Rituximab (anti-CD20) inhibits the proliferation of stimulated human B cells, which is associated with a relative increase of B cells with an activated naive phenotype. Aside from this population shift, there are no major changes in phenotype or cytokine profile of the various B-cell subsets. B cells stimulated in the presence of rituximab induces stronger T-cell proliferation, compared to B cells stimulated in the absence of rituximab. All lymphoma cells tested are equally sensitive to antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-mediated phagocytosis of tumor cells, and rituximab-induced apoptosis. Rituximab (anti-CD20) induces high CDC killing of follicular lymphoma cells. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

A single injection of rituximab or the murine anti-CD20 Ab 1F5, given i.p. 1 day after the tumor, cures 100% of the animals. Depletion of either NK cells or neutrophils or both in tumor-injected animals does not affect the therapeutic activity of the drug. Similarly, rituximab is able to eradicate tumor cells in athymic nude mice, suggesting that its activity is T cell independent. has not independently confirmed the accuracy of these methods. They are for reference only.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

ClinicalTrial

参考文献

[1]. Kamburova EG, et al. In vitro effects of rituximab on the proliferation, activation and differentiation of human B cells. Am J Transplant. 2012 Feb;12(2):341-50.
[2]. Manches O, et al. In vitro mechanisms of action of rituximab on primary non-Hodgkin lymphomas. Blood. 2003 Feb 1;101(3):949-54.
[3]. Byrd JC, et

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Data Sheet

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