Rituximab|174722-31-7|(利妥昔单抗; Anti-Human CD20 type I, Chimeric Antibody)-陌孚医药/Medlife

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Rituximab (Synonyms: 利妥昔单抗; Anti-Human CD20 type I, Chimeric Antibody)

目录号: PL06036 纯度: ≥98%

CAS No. :174722-31-7

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PL06036-5mg	5mg	¥6923.64	请登录
PL06036-10mg	10mg	询价	询价
PL06036-50mg	50mg	询价	询价

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中文名称	Rituximab
中文别名	利妥昔单抗;利妥昔单抗美罗华 Rituximab
英文名称	Rituximab
英文别名	IDEC 102;IDEC-C 2B8;ImmunoglobulinG 1 (human-mouse monoclonal IDEC-C2B8 g1-chain anti-human antigen CD 20), disulfide withhuman-mouse monoclonal IDEC-C2B8 k-chain, dimer;MabThera;Retuxin;Rituxan;Rituximab;Immunoglobulin G1;Immunoglobulin G1,anti-(human CD20 (antigen)) (human-mouse monoclonal IDEC-C2B8 g1-chain), dis...;Immunoglobulin G1,anti-(human CD20 (antigen)) (human-mouse monoclonal IDEC-C2B8 g1-chain), disulfide withhuman-mouse monoclon;Hsdb 7455;Unii-4F4X42syq6;Ig gamma-1 chain C region;IMMunoglobulin G1,anti-(huMan CD20 (antigen)) (huMan-Mouse Monoclonal IDEC-C2B8 g1-chain), disulfide withhuMan-Mouse Monoclonal IDEC-C2B8 k-chain, diMer;Immunoglobulin G 1 (human-mouse monoclonal idec-C2B8 gamma1-chain anti-human antigen cd 20), disulfide with human-mouse monoclonal idec-C2B8 kappa-chain, dimer;Mab thera
Cas No.	174722-31-7
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情

Rituximab 是一种抗 CD20 嵌合单克隆抗体，用于某些自身免疫疾病和癌症的研究。

生物活性

Rituximab is an anti-CD20 chimeric monoclonal antibody used to treat certain autoimmune diseases and types of cancer.

性状

Liquid

体外研究(In Vitro)

Rituximab inhibits the proliferation of stimulated human B cells, which is associated with a relative increase of B cells with an activated naive phenotype. Aside from this population shift, there are no major changes in phenotype or cytokine profile of the various B-cell subsets. B cells stimulated in the presence of rituximab induces stronger T-cell proliferation, compared to B cells stimulated in the absence of rituximab. All lymphoma cells tested are equally sensitive to antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-mediated phagocytosis of tumor cells, and rituximab-induced apoptosis. Rituximab induces high CDC killing of follicular lymphoma cells. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

A single injection of rituximab or the murine anti-CD20 Ab 1F5, given i.p. 1 day after the tumor, cures 100% of the animals. Depletion of either NK cells or neutrophils or both in tumor-injected animals does not affect the therapeutic activity of the drug. Similarly, rituximab is able to eradicate tumor cells in athymic nude mice, suggesting that its activity is T cell independent. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

ClinicalTrial

参考文献

[1]. Kamburova EG, et al. In vitro effects of rituximab on the proliferation, activation and differentiation of human B cells. Am J Transplant. 2012 Feb;12(2):341-50.
[2]. Manches O, et al. In vitro mechanisms of action of rituximab on primary non-Hodgkin lymphomas. Blood. 2003 Feb 1;101(3):949-54.
[3]. Byrd JC, et

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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