Panitumumab|339177-26-3|(ABX-EGF)-陌孚医药/Medlife

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Panitumumab (Synonyms: ABX-EGF)

目录号: PL06017 纯度: ≥98%

CAS No. :339177-26-3

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PL06017-50mg	50mg	询价	询价
PL06017-100mg	100mg	询价	询价

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中文名称	Panitumumab
中文别名	帕尼单抗
英文名称	Panitumumab
英文别名	Panitumumab;ABX-EGF;Abenix;Vectibix
Cas No.	339177-26-3
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情

Panitumumab (ABX-EGF) 是一种全人源 IgG2 抗 EGFR 单克隆抗体，具有抗肿瘤活性。Panitumumab 抑制肿瘤细胞增殖、存活和血管生成。Panitumumab 可用于癌症研究，例如结肠癌。

生物活性

Panitumumab (ABX-EGF) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab can be used in the research of cancers, such as colon cancer.

性状

Liquid

体外研究(In Vitro)

Panitumumab (2 nM-2 μM, 3 h) inhibits ligand-dependent autophosphorylation in EGFR-expressing NCI-H1975 cells, NCI-H1650 cells and CHO cells.
Panitumumab (0-200 μg/mL, 48 h) inhibits the proliferation of DLD-1 cells.
Panitumumab (80 μg/mL, 24 h) increase beclin-1 (a marker of autophagy) levels in Caco-2 cells and DLD-1 cells.
has not independently confirmed the accuracy of these methods. They are for reference only.Western Blot Analysis

体内研究(In Vivo)

Panitumumab (25, 100, or 500 μg/mouse, i.p., twice a week) inhibits tumor growth in NCI-H1975 and NCI-H1650 xenografts, compared with control (P < 0.0003). has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

ClinicalTrial

参考文献

[1]. Yu Jo Chua, et al. Panitumumab. Drugs Today (Barc). 2006 Nov;42(11):711-9.
[2]. Stefan Stremitzer, et al. Panitumumab safety for treating colorectal cancer. Expert Opin Drug Saf. 2014 Jun;13(6):843-51.
[3]. Daniel J. Freeman, et al. Activity of panitumumab alone or with chemotherapy in non-small cell lung car

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