Beinaglutide|123475-27-4|(GLP-1 (human))-陌孚医药/Medlife

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Beinaglutide (Synonyms: GLP-1 (human))

目录号: PL05991 纯度: ≥99%

CAS No. :123475-27-4

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中文名称	Beinaglutide
英文名称	Beinaglutide
英文别名	GLP-1 (7-36);38I1O6L31D;His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg;UNII-38I1O6L31D;Beinaglutide [INN];Glucagon like peptide-i (7-36);Beinaglutide;123475-27-4;Glucagon-like-peptide-1 (7-36)
Cas No.	123475-27-4
分子式	C₁₄₉H₂₂₅N₃₉O₄₆
分子量	3298.62
包装储存	Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years；-20°C 1 ye

产品详情

Beinaglutide 是一种重组人 GLP-1 (rhGLP-1) 多肽，与人 GLP-1(7-36) 具有几乎 100% 的同源性。Beinaglutide 在血糖控制、抑制食物摄入和胃排空和促进体重减轻方面表现出依赖于剂量的作用。Beinaglutide 具有研究超重/肥胖和非酒精性脂肪性肝炎 (NASH) 的潜力。

生物活性

Beinaglutide is a recombinant human GLP-1 (rhGLP-1) polypeptide that shares almost 100% homology with human GLP-1 (7–36). Beinaglutide displays does-dependent effects in glycemic control, inhibiting food intake and gastric empty and promoting weight loss. Beinaglutide has the potential for the research of overweight/obesity and nonalcoholic steatohepatitis (NASH).

性状

Solid

体外研究(In Vitro)

Beinaglutide (100 nM; 48 h) increases the expression of phosphorylation of Akt in the adipocytes that were potentiated insulin-stimulated. has not independently confirmed the accuracy of these methods. They are for reference only.Western Blot Analysis

体内研究(In Vivo)

Beinaglutide (0.6, 1.2, 2.4 mg/kg; s.c.; three times per day for 7 consecutive days) shows the ability of glycemic contro, inhibits food intake and weight loss in mouse.
Beinaglutide (150 μg/kg; s.c.; daily for 6 weeks) increases insulin sensitivity of adipocytes. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years；-20°C 1 ye

ClinicalTrial

SequenceShortening

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参考文献

[1]. Fang X, et al. Beinaglutide shows significantly beneficial effects in diabetes/obesity-induced nonalcoholic steatohepatitis in ob/ob mouse model. Life Sci. 2021 Apr 1;270:118966.
[2]. Zhang F, et al. Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice. iScience. 2021 Oct 30;24(12):103382.

溶解度数据	In Vitro: DMSO : 1.79 mg/mL (0.54 mM; ultrasonic and adjust pH to 5 with HCl)

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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