Apelin-12|229961-08-4|-陌孚医药/Medlife

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Apelin-12

目录号: PL05968 纯度: ≥99%

CAS No. :229961-08-4

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中文名称	Apelin-12
英文名称	Apelin-12
英文别名	L-Phenylalanine,L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-;APELIN PRECURSOR (66-77) (HUMAN, BOVINE, MOUSE, RAT);Apelin-12;Apelin-12 (human, bovine, mouse, rat);Apelin-12,(Des-Gln1)-Apelin-13;H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH;L-Phenylalanine,L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-proly...;(DES-GLN1)-APELIN-13 (HUMAN,BOVINE,MOUSE,RAT);(Des-Gln1)-Apelin-13 (huMan,bovine,Mouse,rat),Apelin Precursor (66-77) (huMan,bovine,Mouse,rat),Preproapelin;APELIN 12;Apelin-12 (huMan,bovine,Mouse,rat) (Des-Gln1)-Apelin-13 (huMan,bovine,Mouse,rat),Apelin Precursor (66-77) (huMan,bovine,Mouse,rat),Preproapelin (66-77) (huMan,bovine,Mouse,rat);ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE;RPRLSHKGPMPF-OH;(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-1-[2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-3-hydro
Cas No.	229961-08-4
分子式	C₆₄H₁₀₃N₂₁O₁₄S
分子量	1422.70
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	Apelin-12 是多肽中最有效的 C 端片段之一，对孤儿受体 APJ 受体具有很高的亲和力。Apelin-12 参与体液平衡的调节和摄食的中枢控制。Apelin-12 阻断HIV-1通过 APJ 受体进入。Apelin-12 具有神经保护作用。
生物活性	Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect.
性状	Solid
IC50 & Target[1][2]	HIV-1
体外研究(In Vitro)	Apelin-12 (A12) exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and p38 MAPK signaling pathway in mouse. Administration of exogenous A12 reduces arterial blood pressure in anesthetized rats due to activation of endothelial nitric oxide synthase and exerts a positive inotropic action in failing myocardium of rodents. Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	RPRLSHKGPMPF
参考文献	[1]. Pisarenko OI, et al. Effects of structural analogues of apelin-12 in acute myocardial infarction in rats. J Pharmacol Pharmacother. 2013;4(3):198-203. [2]. Pisarenko OI, et al. Apelin-12 and its structural analog enhance antioxidant defense in experimental myocardial ischemia and reperfusion. Mol Cell Biochem. 2014;391(1-2):241-250.

溶解度数据	In Vitro: H₂O : ≥ 100 mg/mL (70.29 mM)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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